RESULTS
Overall, 452 patients underwent surgery in the above-mentioned period. A total of 29 patients were excluded from the study: 17 patients were excluded due to suspected multiglandular disease preoperatively; 11 patients were excluded due to insufficient data regarding their cure rates or loss to follow-up; 1 patient was excluded due to adenoma resection using a different surgical modality (Da-Vinci).
A total of 423 patients were included in the analysis, 175 in the No IOPTH group and 248 in the IOPTH group. Table 1 presents comparison of demographic and clinical data between the two groups. Although two statistically significant differences were found between the groups (PTH Pre-Op and Calcium Pre-Op), both are clinically insignificant.
Pre-operative concordance between US and Sestamibi in all patients was 76%. The positive predictive value of both modalities for the location of the adenoma as demonstrated during surgery and after the final pathologic report was 90%, and the sensitivity was 74%.
A total of 173 (98.8%) patients from the No IOPTH group demonstrated normalization of calcium levels 6 months after surgery. A similar cure rates were noted in the IOPTH group (246 patients with a cure rate of 99.1%). Only 2 patients from each group were not cured (p=0.725).
The mean operative time was 66.52 minutes (±28.145) in the No IOPTH group, 86.97 (±32.353) minutes in the IOPTH group, 88.28 (±29.594) minutes in the IOPTH-NC group and 86.35 (±33.633) in the IOPTH-C group.
Operative time was significantly longer in the IOPTH group compared to the No IOPTH group (p<0.001). Furthermore, when comparing operative time between the No IOPTH group and the two subgroups (IOPTH-NC and IOPTH-C), we found that operative time was significantly longer in both subgroups regardless of imaging concordance (p<0.001) (Figure 1).