Discussion
We reported on a clinician in Bangladesh who had a persistent COVID-19 negative report while living in close proximity to known COVID-19 cases and visiting one of the countries with the highest death rates. The most prevalent method for severe acute respiratory syndrome‒coronavirus-2 (SARS-CoV-2) testing is based on reverse transcriptase‒polymerase chain reaction (RT-PCR) for the presence of viral RNA. The virus extraction or positive response of polymerase chain reaction (PCR) from phlegm, nasal sample, or throat swab is used to provide a clear diagnosis of corona virus disease 2019 (COVID-19)(9). Because the consequences of swab testing are affected by a variety of factors, along with the period of swab acquisition after the onset of symptoms, the location of the specimen, the shipping of the swab, and the procedures used in swab collection, physicians should not rule out COVID-19 in a widely speculated patient who has traveled to an epidemic zone(10). Thorough viral screening for SARS-CoV-2 infections could help ensure safe aircraft flight during the COVID-19 pandemic and slow the virus’s wide adoption. Unfortunately, the efficiency of these test-and-travel procedures in reducing traveler risk of SARS-CoV-2 transmission of the disease at the community level is uncertain(11). Proven test-and-travel methods for SARS-CoV-2 infection, which include periodic viral diagnostics surrounding airline travel, can lower both passenger chance of infection and population-level SARS-CoV-2 transmission risk when traveling. The clinician performed 13 Covid19 tests (Figure 1) in order to detect for virus infection while traveling across nations. A negative RT-PCR nasopharyngeal swab test does not rule out COVID-19. As a result, putting too much faith in test results could be harmful, and the demand for widespread testing could be exaggerated. Furthermore, avoiding attempting to test the many numbers, if not millions, of mild COVID-19 instances could save a significant quantity of personal protective equipment. Barrier protection and preemptive behavior, such as acquiring travel or having vaccinated before traveling overseas, is influenced by personal healthcare and well-being perspectives(12, 13). Masking, social dispersion, handwashing, cleansing of commonly handled items, better ventilation, self-isolation, and confinement are among the nonpharmaceutical measures advised to minimize SARS-CoV-2 transfer. Vaccines are the most effective way to avoid the SARS-CoV-2 outbreak. Numerous vaccinations are being developed in many countries using various approaches. The cornerstone of attempts to control the propagation of SARS-CoV-2 has been preventing transmission to the virus and, more recently, immunization against the virus(14). The percentage of false-negative SARS-CoV-2 results from patient respiratory samples varies between 1 and 30%(15). There is no screening test that offers 100% sensitivity and specificity. Despite the fact that the RT-PCR test seems to have become the best model for detecting SARS-CoV-2 virus, false-negative incidences have been observed. These false-negative results can occur for a variety of causes, including detecting either early or too late in the virus’s pathogenic process, inefficient or defective sample collecting techniques, incorrect specimen aspects, low analytic sensitivity, low viral load, or viral shedding mutability. These false-negative findings could have major ramifications, opening the path for positive case aggregations to lead to adverse outcomes and increased transmission rates throughout the population. Because false negative RT-PCR results in cases of COVID-19 are not rare, researchers advocate collecting upper respiratory tract samples in the acute stage and lower respiratory samples or stool samples in the non-acute period(16). Doctors in India who are intensively examining the second wave state that bronchoalveolar lavage done on RT-PCR negative patients with COVID-19 symptoms produced COVID-19 positive results. According to a doctor quoted in the same source, 15 to 20% of COVID-19 patients come with the aforementioned issue, which is posing a problem for doctors(17). In another study, a scientist said that alterations in the SARS-CoV-2 virus may have enabled it to evade RT-PCR testing, and that the reagents must be re-configured immediately(18). Furthermore, epidemiology, background of exposure, and clinical signs such as fever or pulmonary disease should all be examined when establishing COVID-19. As a result, combining serum IgM/IgG antibody identification, nucleic acid testing, CT scan, and clinical characteristics increases COVID-19 accuracy rate. By falsely claiming that an infected individual does not have a disease, a false-negative test puts the entire society at danger. As a result, this individual may spread infection throughout the population. False negatives in group testing are far more dangerous than false positives in solo testing.