Behnammanesh et al., 2019
|
HUVECs HAECs Mice aortic ECs
|
CANA (0-50 µM)/
1-3 d
|
…
|
Angiogenesis ↓ Cell proliferation ↓ Cyclin A and retinoblastoma
phosphorylation ↓
|
Cappetta et al., 2020 |
HUVECs |
DAPA (1 µM) |
… |
NHE
activity ↓ |
|
Rat vasculature
|
DAPA (0.1 mg/kg/d)/ 6 w
|
High-salt (8% NaCl)/
11 w
|
VCAM-1 ↓ NF-κB ↓
|
Cooper et al., 2019
|
HAECs
|
EMPA (50 µM)/24 h
|
TNF-α (10 µg/ml)/
24 h
Wall shear stress (10 dyne/cm2)/24 h
|
Leukocyte-endothelium adhesion ↓ Glycocalyx integrity ↑
|
Ganbaatar et al., 2020 |
Abdominal aorta of Apo
E-/- mice |
EMPA (20 mg/kg/d)/ 8-12 w |
STZ (75 mg/kg) |
NOX2 ↓ Macrophage accumulation ↓ Monocyte chemoattractant protein-1 ↓
ICAM-1↓ |
Gaspari et al., 2018
|
HUVECs
|
DAPA (1 nM-1 mM)/ 24 h
|
TNF-α (10 ng/ml)/
24 h
Hyperglycaemia
(10-30 mM)/24 h
|
ICAM-1 ↓ VCAM-1 ↓ NF-κB ↓
|
|
Aortic sections of Apo E-/- mice
|
DAPA (1 mg/kg/d)/
4 w
|
High-fat diet (22% fat+0.15% cholesterol)/ 20 w
|
ICAM-1 ↓
|
Juni et al., 2019 |
Human CMECs |
EMPA (1 µM)/6 h |
TNF-α (10
ng/ml)/6 h |
Cytoplasmatic ROS ↓ Mitochondrial ROS ↓ NO bioavailability
↑ |
Juni et al., 2021
|
Human CMECs
|
EMPA (1 µM)/6 h
|
Uremic serum (15%)/
6 h
|
Cytoplasmatic ROS ↓ Mitochondrial ROS ↓ Mitochondrial fragmentation ↓ NO
bioavailability ↑
|
Kaji et al., 2018 |
HUVECs |
CANA (10 µM)/12 h |
Co-culture with
Huh7 and HepG2/24 h |
HUVEC proliferation ↓ Tubular formation ↓ IL-8 ↓
Angiogenin ↓ Metalloproteinase-1 ↓ |
Khemais-Benkhiat et al., 2020
|
Porcine coronary artery ECs
|
EMPA (0.1-100 nM)/
30 min-96 h
|
High glucose (25 mmol/L)/48 or 96 h
|
Senescence associated‐beta‐galactosidase ↓
p-21 & p-16 protein ↓
ROS ↓
NOX ↓
eNOS & NO ↑
Glucose uptake ↓
VCAM-1 ↓
|
|
Porcine coronary segment
|
EMPA (100 nM)/
30 min
|
High glucose
(25 mmol/L)/24 h
|
SGLT-1 & 2↓
eNOS ↑
VCAM-1 ↓
|
Leng et al., 2016
|
Aortic sections of Apo E-/- mice
|
DAPA (1.0 mg/kg/d)/
12 w
|
STZ (130 mg/kg)
+high-fat diet (15% fat+0.15% cholesterol)/4 w
|
ROS ↓ NLRP3 inflammasome ↓
|
Li et al., 2021 |
HCAECs |
EMPA (1 µM)/24 h DAPA (1 µM)/24 h CANA
(3 µM)/24 h |
Cyclic stretch (1 Hz, 10%)/24 h |
ROS ↓ Cell permeability
↓ VE-cadherin ↑ |
Luo et al., 2021
|
HUVECs
|
CANA (10 & 20 µM)/
24 h
|
Co-culture with HepG2/24 h
|
Angiogenesis ↓
VEGF-A protein ↓
|
Madonna et al., 2021
|
HAECs
|
EMPA (100 &
300 nM)/0-48 h DAPA (100 nM)/
0-48 h
|
PON (1.7 nM)/0-48 h
|
Tube formation ↑ Cell viability ↑ Autophagy ↑ Senescence ↑
|
Mancini et al., 2018
|
HUVECs HAECs
|
CANA (10 µM)/
6 & 24 h
|
IL-1β (10 ng/ml)/ 6 & 24 h
|
IL-6 ↓ Monocyte chemoattractant protein-1 ↓ Monocyte adhesion ↓ AMPK
activity ↑
|
Nikolaou et al., 2021
|
Mice CMECs
|
EMPA (10 mg/kg/d)/
6 w
|
Ischaemia (30 min)/ Reperfusion (2 h)
|
VEGF ↑ Superoxidedimutase 2 ↑ Cell survival ↑
|
|
Human CMECs |
EMPA (500 nM)/24 h |
Hypoxia (3 h)/ Reoxygenation (1 h) |
Cell viability ↑ ROS ↓ |
Park et al., 2021
|
Porcine coronary artery ECs
|
EMPA or sotagliflozin (100 nM)/30 min-24 h
|
Ang II (100 nM)
|
ROS ↓
SGLT-1 & 2 ↓
Senescence associated‐beta‐galactosidase ↓
eNOS & NO ↑
|
|
Porcine coronary artery ECs
|
EMPA or sotagliflozin (100 nM)/48 h
|
Microparticles from patients with coronary artery disease
(10 nM)/48 h
|
SGLT-1 & 2 ↓
eNOS & NO ↑
VCAM-1 ↓
|
Ortega et al., 2019
|
Aortic aneurysm sections of Apo E-/- mice
|
EMPA (3 mg/kg/d)/
28 d
|
Ang II (1000 ng/kg/d)/
28 d
|
Macrophage infiltration ↓ p38 MAPK ↓ NF-κB ↓ VEGF ↓
|
|
HAECs |
EMPA (3 µM)/24 h |
Ang II (1 µM)/24 h |
Leukocyte-endothelium
interactions ↓ ICAM-1 ↓ VCAM-1 ↓ |
Salim et al., 2016
|
Mice abdominal aorta
|
Ipragliflozin
(3 mg/kg/d)/3 w
|
STZ (150mg/lkg)
|
Akt phosphorylation ↑ eNOS phosphorylation ↑ Monocyte chemoattractant
protein-1 ↓ ICAM-1 ↓ VCAM-1 ↓
|
Uthman et al., 2019 |
HCAECs HUVECs |
EMPA (1 µM)/4-24 h DAPA (1
µM)/4-24 h |
TNF-α (10 ng/ml)/ 4-24 h |
ROS ↓ NO bioavailability
↑ |
Uthman et al., 2020 |
HCAECs |
CANA (10 µM)/16 h |
Lipopolysaccharide (1 µg/ml)/16 h |
IL-6 ↓ ERK1/2 phosphorylation ↓ AMPK
phosphorylation ↑ HK II ↓ |
Uthman et al., 2022 |
HCAECs HUVECs |
EMPA (1 µM)/6 h |
TNF-α (10
ng/ml)/6 h |
NHE activity ↓ Intracellular Na+ ↓ ROS ↓ |
Zhou et al., 2018 |
Mice CMECs |
EMPA (10 mg/kg/d)/ 20 w |
STZ
(50mg/kg)/5 d |
Angiogenesis ↑ Migration ↑ Wound healing ↑ Cytoplasmatic
ROS ↓ Mitochondrial ROS ↓ Mitochondrial fission and fusion ↓ Senescence
↓ |