Abstract
Neuroendocrine tumors are a heterogeneous group of tumors with a wide
range of malignant potential that tend to have a relative prolonged
course. These tumors infrequently metastasize to the orbit. Ocular
metastases from pancreatic neuroendocrine tumors (PNETs) have never been
reported in the literature.
We report the case of a 61-year-old man who presented with progressive
deterioration of general condition with unilateral recurrent episodes of
non-granulomatous panuveitis of the left eye related to a choroidal
metastasis. Radiological imaging and histopathological analyses led to
the diagnosis of metastatic pancreatic neuroendocrine carcinoma as the
primary tumor.
Choroidal metastases from neuroendocrine tumors are extremely rare, but
compromise patients’ well-being because of visual impairment.
Uncommonly, these metastases can be the first manifestation of unknown
tumors, warranting further investigations to detect the primary cancer.