Statistical Analysis
The statistical software RStudio Team (version 1.2.5033 [2019],
RStudio: Integrated Development for R. RStudio, Inc., Boston, MA URL:http://www.rstudio.com/) was used for
statistical analysis. Categorical data were reported as frequency and
percentage, and comparisons between groups were performed by chi-square
or Fisher tests, as appropriate. Continuous variables were reported as
the median and interquartile range, and the Mann-Whitney U test was used
to assess differences between groups. Receiver-operating-characteristic
(ROC) curves were generated and detection rates (DR) at fixed 5%, 10%,
15%, 20%, 25% and 30% false-positive rates (FPR) were calculated for
both algorithms. The predictive accuracies of both algorithms were
compared for a fixed FPR of 10% as well as for the resulting areas
under the curve (AUC), which were compared by the Delong
test20. The Bonferroni correction was used in all
tests when multiple comparisons were assessed. Statistical significance
level was set at p<0.05.