Summary of study participants
Study participants included four families with 3-6 losses and 2-4 live
births (Table 1 ). Participants’ maternal and paternal ages
ranged between 25-34 and 34-36 years, respectively. All maternal and
paternal participants self-identified as non-Hispanic White.
Race/ethnicity inferred from the genotype of the participants suggested
White/Hispanic, i.e., admixed Americans for the Family 2 mother and
White/non-Hispanic, i.e., Western European ancestry for all other
participants. Family 3 had an abnormal karyotype stillborn fetus in
their second pregnancy. Samples were available from an embryonic loss at
5 weeks and 6 days (Family 3), fetal deaths at 15 weeks and 6 days,
13-20 weeks, and 13 weeks and 6 days (Family 1), 17 weeks and 6 days,
and 18 weeks and 6 days (Family 4), and stillbirths at 20 weeks (Family
1), 20-23 weeks (Family 2) and 20-40 weeks (Family 3). Samples from live
births (n=10 from four families) were healthy babies born after 37
weeks.