Mode of Inheritance Pregnancy loss Pregnancy loss Pregnancy loss Live birth Live birth Live birth Total p-value*
Total pLI > 0.9; LOEUF < 0.35 pLI < 0.9; LOEUF > 0.35 Total pLI > 0.9; LOEUF < 0.35 pLI < 0.9; LOEUF > 0.35
Autosomal Dominant, n (%)
296 (47.1)
56 (8.9) 240 (38.2)
332 (52.9)
68 (10.8)
264 (42.0)
628 (100.0)
0.15
De novo, n (%)
108 (92.3)
22 (18.8) 86 (73.5) 9 (7.7) 2 (1.7) 7 (6.0)
117 (100.0)
<0.001
Compound Heterozygous, n (%)
27 (42.2)
5 (7.8) 22 (34.4)
37 (57.8)
5 (7.8) 32 (50.0)
64 (100.0)
0.21
Total, n (%)
432 (53.3)
84 (10.4) 348 (43.0)
378 (46.7)
75 (9.3)
303 (37.4)
810 (100.0)
0.06