Methods
We conducted a pilot WGS study of four families with recurrent pregnancy
loss, including parents, healthy live births, and losses, which included
an embryonic loss (<10 weeks’ gestation), fetal deaths (10-20
weeks’ gestation) and stillbirths (≥ 20 weeks’ gestation). We used the
Illumina platform for WGS and state-of-the-art protocols to identify
single nucleotide variants (SNVs) following various modes of
inheritance.