1. Little is known about the prevalence, specificity,
patterns and temporal changes of sensitization to most airborne fungi.
We suggest tackling the fungal sensitization landscape, defined as the
detectable IgE sensitization, its molecular targets and the putative
clusters of relevant allergen families among a panel of fungal
allergens. This panel should aim to fully represent the fungal exposome
and its longitudinal evolution. Harnessing expertise in fungal ecology,
fungal culture requirements, fungal allergen biochemistry including
further characterization of allergens, cohort studies, fungus-induced
immune responses, large-scale analysis of allergen investigations, and
big data analysis will be necessary