Temporal and Geographical Distribution Analysis.
A total of 683 Chinese CPV-2 records were retrieved from Genbank and related publications. The details were presented in Supporting Information. Additionally, 23 strains (collected from 2018 to 2019) in this study were included.
The temporal distribution analysis was given in Figure 3. The detection rate of New CPV-2a has declined since 2016, and New CPV-2b showed the same tendency. In contrast, CPV-2c has been consistently growing since 2014, thereby replacing New CPV-2a as the predominant variant in China after 2018.
Figure 3 Temporal Distribution of CPV-2 in China from 2014-2019.
Considering the dynamic change of the genotype of Chinese CPV-2 strains in recent years, the geographical distribution analysis was divided into two periods. The former was from 2014 to 2016, and the latter was from 2017 to 2019. Their respective data was given in Figure 4.