Figure 4: HDL levels at 2 weeks and 16 weeks of treatment. D+A; diabetic mice treated with Vitamin A *P<0.05 compared to control nondiabetic mice, **P<0.05 compared to diabetic mice.
Total cholesterol was examined at week 2 and week 16 post-injection. At two weeks both untreated and treated diabetic mice showed a significant increase in their total cholesterol levels (5.8 ± 2.9 mmol/l, 5.9 ± 2.4 mmol/l, P  < 0.05, respectively) compared with that of normal mice. At 16 week treated diabetic mice showed a significant decrease in their total cholesterol levels (1.9 ± 0.9 mmol/l, P  < 0.05) compared with that of untreated mice (Figure 5).