Definiton of Appropriate Use of Aspirin
The appropriate use of aspirin was evaluated according to the USPTF and
ESC guidelines in the primary prevention group. The ESC guidelines do
not recommend aspirin for primary prevention (6). The USPTF guidelines
suggest aspirin for adults age 40 to 70 at higher risk of
atherosclerotic CVD without higher bleeding risk (8). Therefore, we
defined aspirin use as inappropriate for all patients according to the
ESC guidelines and for patients younger than 40, elder than 70, ASCVD
score < 10% and, in those at high bleeding risk according to
the USPTF guidelines.