METHODOLOGY
This is a narrative review of the literature performed in the PUBMED and
Virtual Health Library databases through the combination of descriptors
in health sciences (Table 1). After applying the search and selection
criteria, original studies were included, without language and
publication time restrictions, dealing with biguanides and their
pharmacological effects. Those who did not have a control group were
excluded, when the intervention was only in association, when it did not
specify the treatment of data, as well as duplicity. The data were
extracted: author, year of publication, objectives, method, experimental
design, experimental model, follow-up time, intervention, posological
scheme, main results and bibliographic references (submitted to the
cited criteria). No evaluation by the Research and Ethics Committee was
necessary.