Statistical Analysis
P-Pharm (Simed) software was used to analyse the data and determine theEmax and ED50 values using
the no-intercept Emax model (22,26). The data
sets for each of the TCs and TCPs were analysed with the log-normal
distribution assumption for ED50 to fit theEmax model (22) according to Equation 1 that
describes the elicited effect (E ) in terms a maximal effect
(Emax ), dose (D ) and the dose at which the
effect is half-maximal (ED50 ).