Strength of evidence GRADE reporting system
The results of the quality of evidence assessment regarding the comparison of insulin, glucose and adiponectin levels, as well as HOMA-IR, before and after treatment with systemic isotretinoin are shown in Appendix, Table S2. Adiponectin, insulin, and glucose levels were judged to be of “High” strength of evidence, while HOMA-IR was judged to be of “Moderate” level of evidence.