Inclusion and Exclusion Criteria
We searched for Randomized Controlled Trials (RCTs), Cohort and Case-Control studies comparing the serum levels of adiponectin, insulin, and glucose, as well as the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) before and after systematic treatment with isotretinoin in patients with acne vulgaris. We included only studies with a published full text in English.