Search results
The PRISMA flow diagram of search results is shown in Figure 1. After the removal of 67 duplicates, 317 studies were screened per Title and Abstract. A total of 16 studies qualified for assessment of eligibility. Finally, 1 study 18 was excluded according to the exclusion criteria, while 15 studies 7,8,19–31 were found eligible for qualitative and quantitative analysis including 380 acne vulgaris patients under systematic isotretinoin.