Insulin
Ten studies 7,19–21,23–26,28,29 that assessed insulin levels in serum before and after treatment with systemic isotretinoin were meta-analyzed. No statistically significant difference was found in insulin levels before and after treatment [pooled SMD: 0.17, 95% CI (-0.41 - 0.76), p-value: 0.56; I2: 89%]. Despite the conducted subgroup analysis, the high statistical heterogeneity remained (I2>75%), with none statistically significant result (Appendix, Figures S5-S7).