Conclusion
To conclude, in accordance with the systematic review and meta-analysis
performed, isotretinoin treatment in acne patients significantly
increases serum adiponectin levels but does not substantially alter
insulin resistance (HOMA - IR). Further research including multicenter
randomized controlled trials is needed to both reveal the
pathophysiological pathway that associates isotretinoin with insulin
resistance and the role of serum adiponectin in this correlation.
Authors’ Individual Contributions: Eleni Paschalidou and
Georgios N. Katsaras: conceived the study, participated in its design,
collection and interpretation of the data, and also performed the data
collection and extraction, as well as the statistical analyses, and
helped to draft the manuscript. Thomas Papoulakis and Evangelia
Kalloniati: participated in conceptualization and the design of the
study, collection and interpretation of the data; and also performed the
data collection and extraction, as well as the statistical analyses, and
drafting the manuscript. Dimitrios Kavvadas and Sophia Karachrysafi:
contributed to the analysis of the results and in drafting the
manuscript. Dorothea Kapoukranidou, Georgios Tagarakis and Theodora
Papamitsou: supervised the methodology and statistical analyses and
edited the final draft of the manuscript.
All authors critically revised the paper for important intellectual
content and approved the final version to be published.
Funding Information: There was no funding.
Conflicts of interest: The authors have no conflicts of
interest to disclose.