Insulin
Ten studies 7,19–21,23–26,28,29 that assessed
insulin levels in serum before and after treatment with systemic
isotretinoin were meta-analyzed. No statistically significant difference
was found in insulin levels before and after treatment [pooled SMD:
0.17, 95% CI (-0.41 - 0.76), p-value: 0.56; I2:
89%]. Despite the conducted subgroup analysis, the high statistical
heterogeneity remained (I2>75%), with
none statistically significant result (Appendix, Figures S5-S7).