Search Strategy and Sources
The research strategy was designed based on the Peer Review of Electronic Search Strategies (PRESS) checklist 10using free text and Medical Subject Heading (MeSH) terms and their synonyms. Search terms were ”isotretinoin”, “acne”, “insulin resistance” and ”adiponectin” with synonyms and alternatives. Apart from language, no filters, geographical, publication status, and year restrictions were applied (Appendix, Table S1).
The following databases were searched by two reviewers (EP, GNK) independently: Pubmed/ Medline, Scopus, and Cochrane Library. PROSPERO (International Prospective Register of Systematic Reviews) database was likewise searched for ongoing SRMAs. The last searches were conducted on the 12th of January 2022.