HOMA-IR
We meta-analyzed HOMA-IR before and after treatment with systemic isotretinoin from 11 studies7,8,29,19,20,22–26,28. No statistically significant difference was found in HOMA-IR before and after treatment [pooled SMD: 0.04, 95% CI (-0.16 - 0.24), p-value: 0.67; I2: 21%]. Despite the conducted subgroup analysis, none statistically significant result was found (Appendix, Figures S8-S10).