References
1. Fox L, Csongradi C, Aucamp M, du Plessis J, Gerber M. Treatment Modalities for Acne. Molecules . 2016;21(8). doi:10.3390/molecules21081063
2. Gollnick H, Cunliffe W, Berson D, et al. Management of acne: a report from a Global Alliance to Improve Outcomes in Acne. J Am Acad Dermatol . 2003;49(1 Suppl):S1-37. doi:10.1067/mjd.2003.618
3. Katsambas A, Papakonstantinou A. Acne: systemic treatment. Clin Dermatol . 22(5):412-418. doi:10.1016/j.clindermatol.2004.03.014
4. Zouboulis CC, Piquero-Martin J. Update and future of systemic acne treatment. Dermatology . 2003;206(1):37-53. doi:10.1159/000067821
5. Hermans MP, Valensi P. Elevated triglycerides and low high-density lipoprotein cholesterol level as marker of very high risk in type 2 diabetes. Curr Opin Endocrinol Diabetes Obes . 2018;25(2):118-129. doi:10.1097/MED.0000000000000398
6. Fang H, Judd RL. Adiponectin Regulation and Function. Compr Physiol . 2018;8(3):1031-1063. doi:10.1002/cphy.c170046
7. Ertugrul DT, Karadag AS, Tutal E, Akin KO. Isotretinoin does not induce insulin resistance in patients with acne. Clin Exp Dermatol . 2011;36(2):124-128. doi:10.1111/j.1365-2230.2010.03915.x
8. Soyuduru G, Özsoy Adişen E, Kadioğlu Özer İ, Aksakal AB. The effect of isotretinoin on insulin resistance and adipocytokine leveacne vulgaris patients. Turkish J Med Sci . 2019;49(1):238-244. doi:10.3906/sag-1806-44
9. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ . 2021;372. doi:10.1136/BMJ.N71
10. McGowan J, Sampson M, Salzwedel DM, Cogo E, Foerster V, Lefebvre C. PRESS Peer Review of Electronic Search Strategies: 2015 Guideline Statement. J Clin Epidemiol . 2016;75:40-46. doi:10.1016/j.jclinepi.2016.01.021
11. Cochrane Effective Practice and Organization of Care (EPOC). Screening, data extraction and management. EPOC Resourcces Rev authors. Published 2021. Accessed June 28, 2021. https://epoc.cochrane.org/resources/epoc-resources-review-authors
12. Lebovitz HE. Insulin resistance definition and facts. Exp Clin Endocrinol Diabetes . 2001;109:135-148.
13. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man.Diabetologia . 1985;28(7):412-419. doi:10.1007/BF00280883
14. Sterne J, Hernán M, McAleenan A, Reeves B, Higgins J. Assessing risk of bias in a non-randomized study. In: Higgins J, Thomas J, Chandler J, et al., eds. Cochrane Handbook for Systematic Reviews of Interventions Version 6.0 . 6th ed. Cochrane; 2019.
15. McGuinness LA, Higgins JPT. Risk‐of‐bias VISualization (robvis): An R package and Shiny web app for visualizing risk‐of‐bias assessments.Res Synth Methods . 2021;12(1):55-61. doi:10.1002/jrsm.1411
16. GRADE (Grading of Recommendations Assessment Development and Evaluation System). The GRADE Working Group. Accessed July 4, 2021. https://www.gradeworkinggroup.org/
17. GRADEpro GDT. McMaster University and Evidence Prime Inc. Published 2020. Accessed August 12, 2021. https://gradepro.org/
18. Karapınar T, Polat M, Buğdaycı G. Evaluation of subclinical atherosclerosis in Turkish patients with acne vulgaris receiving systemic isotretinoin. Dermatol Ther . 2020;33(3). doi:10.1111/dth.13307
19. Saklamaz A, Uyar B, Yalcin M, Cengiz H. Isotretinoin increased carotid intima-media thickness in acne patients. Hippokratia . 2016;20(1):14-18.
20. Aydin K, Çetinözman F, Elcin G, Aksoy DY, Ucar F, Yildiz BO. Suppressed Adiponectin Levels and Increased Adiponectin Response to Oral Glucose Load in Lean Women with Severe Acne Normalizes after Isotretinoin Treatment. Dermatology . 2017;233(4):314-319. doi:10.1159/000484168
21. Acmaz G, Cinar L, Acmaz B, et al. The Effects of Oral Isotretinoin in Women with Acne and Polycystic Ovary Syndrome. Biomed Res Int . 2019;2019. doi:10.1155/2019/2513067
22. Koçyiğit SE, Şahin M, Houshyar Y, Dost Günay FS, Çorapçioğlu D. Effects of isotretinoin treatment on levels of hormones involved in the etiopathogenesis of acne. Turkish J Endocrinol Metab . 2020;24(3):237-246. doi:10.25179/tjem.2020-75230
23. Aktar R, Gunes Bilgili S, Yavuz IH, et al. Evaluation of hirsutism and hormonal parameters in acne vulgaris patients treated with isotretinoin. Int J Clin Pract . 2021;75(3):e13791. doi:10.1111/ijcp.13791
24. Laker MF, Green C, Bhuiyan AK, Shuster S. Isotretinoin and serum lipids: studies on fatty acid, apolipoprotein and intermediary metabolism. Br J Dermatol . 1987;117(2):203-206. doi:10.1111/j.1365-2133.1987.tb04117.x
25. Koistinen HA, Remitz A, Gylling H, Miettinen TA, Koivisto VA, Ebeling P. Dyslipidemia and a reversible decrease in insulin sensitivity induced by therapy with 13-cis-retinoic acid. Diabetes Metab Res Rev . 2001;17(5):391-395. doi:10.1002/dmrr.222
26. Stoll D, Binnert C, Mooser V, Tappy L. Short-term administration of isotretinoin elevates plasma triglyceride concentrations without affecting insulin sensitivity in healthy humans. Metabolism . 2004;53(1):4-10. doi:10.1016/j.metabol.2003.07.006
27. Koistinen HA, Remitz A, Koivisto VA, Ebeling P. Paradoxical rise in serum adiponectin concentration in the face of acid-induced insulin resistance 13-cis-retinoic. Diabetologia . 2006;49(2):383-386. doi:10.1007/s00125-005-0089-z
28. Heliövaara MK, Remitz A, Reitamo S, Teppo A-M, Karonen S-L, Ebeling P. 13-cis-Retinoic acid therapy induces insulin resistance, regulates inflammatory parameters, and paradoxically increases serum adiponectin concentration. Metabolism . 2007;56(6):786-791. doi:10.1016/j.metabol.2007.02.002
29. Cetinözman F, Aksoy DY, Elçin G, et al. Insulin sensitivity, androgens and isotretinoin therapy in women with severe acne. J Dermatolog Treat . 2014;25(2):119-122. doi:10.3109/09546634.2012.751482
30. Karadag AS, Ertugrul DT, Takci Z, et al. The Effect of Isotretinoin on Retinol-Binding Protein 4, Leptin, Adiponectin and Insulin Resistance in Acne Vulgaris Patients. Dermatology . 2015;230(1):70-74. doi:10.1159/000367687
31. Cemil BC, Ayvaz HH, Ozturk G, et al. Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients. Adv Dermatology Allergol . 2016;4(4):294-299. doi:10.5114/pdia.2016.56928
32. Tsai T-Y, Liu H-W, Chao Y-C, Huang Y-C. Effects of isotretinoin on glucose metabolism in patients with acne: A systematic review and meta-analysis. J der Dtsch Dermatologischen Gesellschaft = J Ger Soc Dermatology JDDG . 2020;18(6):539-545. doi:10.1111/ddg.14108
33. Tsukada M, Schro M, Roos TC, et al. 1 321 3-. Published online 2000.
34. Melnik BC. p53: Key conductor of all anti-acne therapies. J Transl Med . 2017;15(1):1-12. doi:10.1186/s12967-017-1297-2
35. Agamia NF, Hussein OM, Abdelmaksoud RES, et al. Effect of oral isotretinoin on the nucleo-cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgaris. Exp Dermatol . 2018;27(12):1344-1351. doi:10.1111/exd.13787
36. Wilson, M.S. , Metink-Kane MM. 基因的改变NIH Public Access.Bone . 2012;23(1):1-7. doi:10.1016/j.biochi.2012.01.008.Up-
37. Moseti D, Regassa A, Kim WK. Molecular regulation of adipogenesis and potential anti-adipogenic bioactive molecules. Int J Mol Sci . 2016;17(1):1-24. doi:10.3390/ijms17010124
38. Hino K, Nagata H. Screening for Adiponectin Secretion Regulators . Vol 90. 1st ed. Elsevier Inc.; 2012. doi:10.1016/B978-0-12-398313-8.00005-1
39. Qiao L, Shao J. SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer- binding protein α transcriptional complex. J Biol Chem . 2006;281(52):39915-39924. doi:10.1074/jbc.M607215200
40. Landrier JF, Kasiri E, Karkeni E, et al. Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue. FASEB J . 2017;31(1):203-211. doi:10.1096/fj.201600263RR
41. Kalisz M, Chmielowska M, Martyńska L, Domańska A, Bik W, Litwiniuk A. All-trans-retinoic acid ameliorates atherosclerosis, promotes perivascular adipose tissue browning, and increases adiponectin production in Apo-E mice. Sci Rep . 2021;11(1):1-11. doi:10.1038/s41598-021-83939-x
42. Ahmed B, Sultana R, Greene MW. Adipose tissue and insulin resistance in obese. Biomed Pharmacother . 2021;137:111315. doi:10.1016/j.biopha.2021.111315
43. Samuel VT, Shulman GI. The pathogenesis of insulin resistance: Integrating signaling pathways and substrate flux. J Clin Invest . 2016;126(1):12-22. doi:10.1172/JCI77812
44. Altomonte J, Cong L, Harbaran S, et al. Foxo1 mediates insulin action on apoC-III and triglyceride metabolism. J Clin Invest . 2004;114(10):1493-1503. doi:10.1172/jci19992
45. Rajan MR, Nyman E, Kjølhede P, Cedersund G, Strålfors P. Systems-wide experimental and modeling analysis of insulin signaling through forkhead box protein O1 (FOXO1) in human adipocytes, normally and in type 2 diabetes. J Biol Chem . 2016;291(30):15806-15819. doi:10.1074/jbc.M116.715763