Glucose
Nine studies 7,19,20,23–26,28,29 that assessed glucose levels in serum before and after treatment with systemic isotretinoin were meta-analyzed. No statistically significant difference was found in glucose levels before and after treatment [pooled SMD: -0.03, 95% CI (-0.23 - 0.17), p-value: 0.76; I2: 0%] (Appendix, Figures S3 and S4).