Conclusion
To conclude, in accordance with the systematic review and meta-analysis performed, isotretinoin treatment in acne patients significantly increases serum adiponectin levels but does not substantially alter insulin resistance (HOMA - IR). Further research including multicenter randomized controlled trials is needed to both reveal the pathophysiological pathway that associates isotretinoin with insulin resistance and the role of serum adiponectin in this correlation.
Authors’ Individual Contributions: Eleni Paschalidou and Georgios N. Katsaras: conceived the study, participated in its design, collection and interpretation of the data, and also performed the data collection and extraction, as well as the statistical analyses, and helped to draft the manuscript. Thomas Papoulakis and Evangelia Kalloniati: participated in conceptualization and the design of the study, collection and interpretation of the data; and also performed the data collection and extraction, as well as the statistical analyses, and drafting the manuscript. Dimitrios Kavvadas and Sophia Karachrysafi: contributed to the analysis of the results and in drafting the manuscript. Dorothea Kapoukranidou, Georgios Tagarakis and Theodora Papamitsou: supervised the methodology and statistical analyses and edited the final draft of the manuscript.
All authors critically revised the paper for important intellectual content and approved the final version to be published.
Funding Information: There was no funding.
Conflicts of interest: The authors have no conflicts of interest to disclose.