Search Strategy and Sources
The research strategy was designed based on the Peer Review of
Electronic Search Strategies (PRESS) checklist 10using free text and Medical Subject Heading (MeSH) terms and their
synonyms. Search terms were ”isotretinoin”, “acne”, “insulin
resistance” and ”adiponectin” with synonyms and alternatives. Apart
from language, no filters, geographical, publication status, and year
restrictions were applied (Appendix, Table S1).
The following databases were searched by two reviewers (EP, GNK)
independently: Pubmed/ Medline, Scopus, and Cochrane Library. PROSPERO
(International Prospective Register of Systematic Reviews) database was
likewise searched for ongoing SRMAs. The last searches were conducted on
the 12th of January 2022.