ABSTRACT
Objectives: To explore the effect of intranasal administration
of rh-bFGF on postoperative chronic rhinosinusitis with nasal
polyps(CRSwNP) patients.
Design: A prospective, randomized, controlled, single-blinded
trial.
Setting and Participants: 75 hospitalized patients who met the
criteria of primary bilateral CRSwNP were enrolled from March 2020 to
January 2021.
Main outcome measures: Visual analogue scale, 22 item
Sino-Nasal Outcome Test ,Lund-Kennedy(L-K) system, and Scanning electron
microscopy and Quantitative real-time PCR.
Results: 75 patients with CRSwNP were randomly divided into
three groups, and 72 patients completed the 1-month medication regimen
and 1 year follow-up. Rh-bFGF nasal-spray and drop application reduced
general nasal VAS scores within two weeks after ESS compared to the
control group. In contrast, only rh-bFGF nasal-drops reduced SNOT-22
scores at 2 weeks and 1 year compared to the control group. A
significant reduction in the endoscopic L-K score was observed in the
rh-bFGF nasal-spray and drop group compared to the control group. This
is primarily because rh-bFGF promotes cilia growth in the nasal mucosal
epithelium after the operation, as illustrated by scanning electron
microscopy and expression of CP110, Tap73 and Foxj1 mRNA. For
eosinophilic CRSwNP, the general VAS score of rh-bFGF nasal-drops was
more obviously reduced compared to the control group after ESS. A
similar trend was observed for L-K score.
Conclusions: Rh-bFGF nasal-drops and sprays can quickly and
effectively relieve postoperative symptoms and improve long-term
prognosis of patients with CRSwNP. Moreover, rh-bFGF nasal-drops are
also an effective method for postoperative patients with eosinophilic
CRSwNP.
Keywords: eosinophilic chronic rhinosinusitis; nasal mucosa;
rh-bFGF; nasal-spray; nasal-drop.