Ciliogenesis-associated markers
To further verify the effect of rh-bFGF on the cilia growth, the mRNA
expression of CP110, Tap73 and Foxj1 was detected. The expression of
CP110, Tap73 and Foxj1 in three groups before ESS was on the same
level(Figure4A,D,G). The expression of CP110 and Tap73 of the rh-bFGF
experimental groups was significantly lower than that of control group
after ESS while no statistic difference was found between nasal-spray
group and control group at 2 weeks(Figure4B,C,H,I). The expression of
Foxj1 of the rh-bFGF experimental groups was significantly lower than
that of control group after ESS. However, there was no difference
between nasal-spray group and control group at 1 month(Figure4E,F).