Conclusion
Implementing a standardized, SCA-specific MRA scanning protocol, using short-TE techniques, allowed for re-classification of previously seen stenosis in 12/29 patients (41%). This reclassification resulted in discontinuation of chronic transfusion therapy, which has potentially significant side effects, in six out of 24 patients. Implementation of the TWiTCH trial results is dependent on accurate classification of the grade of vasculopathy on MRA and if low grade, allows the patients to transition to hydroxyurea. Optimizing MRA echo time to <5msec can minimize flow artifact, improve accurate interpretation of true cerebrovascular disease, and impact treatment plans put in place for stroke prevention for pediatric patients with sickle cell anemia.
Acknowledgements: Prince Dhillon, DMD, MD for guidance on figure creation
Sources of Funding: none
Disclosures: none