Conclusion
Implementing a standardized, SCA-specific MRA scanning protocol, using
short-TE techniques, allowed for re-classification of previously seen
stenosis in 12/29 patients (41%). This reclassification resulted in
discontinuation of chronic transfusion therapy, which has potentially
significant side effects, in six out of 24 patients. Implementation of
the TWiTCH trial results is dependent on accurate classification of the
grade of vasculopathy on MRA and if low grade, allows the patients to
transition to hydroxyurea. Optimizing MRA echo time to <5msec
can minimize flow artifact, improve accurate interpretation of true
cerebrovascular disease, and impact treatment plans put in place for
stroke prevention for pediatric patients with sickle cell anemia.
Acknowledgements: Prince Dhillon, DMD, MD for guidance on figure
creation
Sources of Funding: none
Disclosures: none