Search strategy and date extraction
We searched for randomised controlled trials in the review, involving adult patients with plaque psoriasis of trunk and limbs. Only studies that included data from the most recent or comprehensive studies were included under multiple articles involving the same population and we investigated the efficacy, safety and tolerability of topical therapies compared with placebo for patients with plaque psoriasis,in particular some new drugs.An electronic search of the published literature using PubMed, Cochrane Library and Embase databases was conducted by two researchers independently who searched for publications on topical durgs in the treatment of plaque psoriasis and published between 01 January 2010 and 20 February 2022. References within the reviews literature on topical treatment of psoriasis and selected articles were reviewed to avoid missing relevant articles.The following information was extracted from the included first author’s name,publishing date,clinical trial registration number,study country,blind evaluation,the number of participants, baseline patient characteristics (age, gender, PASI), treatment regimen, outcome assessment, and follow-up time.