Hierarchical cluster analysis
Simultaneous ranking of the interventions in terms of efficacy(PGA0/1 or IGA0/1) and safety(AEs) were summarized using a clustered–ranking plot(Figure 3a).Cal/BD,betamethasone, roflumilast and halobetasol formed a large cluster of topical therapies with higher efficacy and safety. Tapinarof shows high efficacy but lowest safety than other treatments. Tofacitinib shows lower efficacy but highest safety than other agents. Clustered ranking was applied to efficacy(PGA0/1 or IGA0/1) and tolerability( Figure 3b) .Cal/BD,betamethasone, roflumilast and HP/TAZ presented in the top–right corner,were higher efficacy and tolerability than orther agents.