INCLUSION CRITERIA:
The definition of MIS-N from CDC criteria was used along with published
definitions to define neonatal COVID infection, [21, 22] and agreed
upon certain inclusion criteria. Once common neonatal conditions
mimicking multi- system presentations (E.g., sepsis, birth asphyxia,
pneumonia, other common condition) were ruled out by the neonatologist,
MIS-N was considered in neonates meeting the following criteria
1. Symptoms presenting from birth to the first four weeks of life.
2. Fever along with two or more systems involvement (fever, if present,
is suggestive but not mandatory for diagnosis in the newborn).
3. Evidence of raised inflammatory markers such as CRP, D Dimer, and
Ferritin.
4. Evidence of SARS-CoV-2 antibodies in the neonate (considered
mandatory for a diagnosis of MIS) and SARS-CoV-2 antigen to be negative
during the presentation to rule out active SARS-CoV-2 infection to
support the immunological
process.