DIAGNOSTIC ASSESSMENT:
All 98 neonates presented were positive titers for SARS CoV 2 IgG
antibodies and negative SARS CoV 2 antigen during the presentation. SARS
CoV 2 antigens were tested on RTPCR in mothers 34 tested positive, SARS
CoV 2 IgG antibodies were positive in 56.
EARLY MIS-N: Inflammatory markers were elevated in these
neonates with raised CRP in 17(30%), D-Dimer 40(70%), Ferritin
17(30%), Elevated cardiac biomarkers like Pro-BNP in 34 (60%), LDH 17
(30%). Hematological parameters showed leukocytopenia 6(10%),
thrombocytopenia 6(10%), Deranged coagulation 6(10%), ECHO parameters
showed LV dysfunction in 34(59%) of cases, PPHN in 12(20%).
LATE MIS-N: Inflammatory markers were elevated in these
neonates with raised CRP in 28(70%), D-Dimer 20(50%), Ferritin
28(70%), Elevated cardiac biomarkers like Pro-BNP in 16(40%), LDH 8
(20%). Hematological parameters showed leucocytosis 8(20%),
leukocytopenia 4 (10%), thrombocytopenia 12(30%), Deranged coagulation
12(30%), ECHO parameters showed LV dysfunction in 12(30%) of cases,
Dilated coronaries 8(20%), PPHN 4(10%) and pericardial effusion
4(10%).
RESPIRATORY SUPPORT :
In early presentation, most neonates required non-invasive ventilation
23(40%), 12(20%) were on ventilator as primary support, 6(10%) on
Nasal Oxygen.
In late MIS-N, respiratory support requirement was low, Noninvasive
4(10%) compared to Early MIS-N neonates, 4 (10%) on ventilator, nasal
oxygen support 8(20%).