DIAGNOSTIC ASSESSMENT:
All 98 neonates presented were positive titers for SARS CoV 2 IgG antibodies and negative SARS CoV 2 antigen during the presentation. SARS CoV 2 antigens were tested on RTPCR in mothers 34 tested positive, SARS CoV 2 IgG antibodies were positive in 56.
EARLY MIS-N: Inflammatory markers were elevated in these neonates with raised CRP in 17(30%), D-Dimer 40(70%), Ferritin 17(30%), Elevated cardiac biomarkers like Pro-BNP in 34 (60%), LDH 17 (30%). Hematological parameters showed leukocytopenia 6(10%), thrombocytopenia 6(10%), Deranged coagulation 6(10%), ECHO parameters showed LV dysfunction in 34(59%) of cases, PPHN in 12(20%).
LATE MIS-N: Inflammatory markers were elevated in these neonates with raised CRP in 28(70%), D-Dimer 20(50%), Ferritin 28(70%), Elevated cardiac biomarkers like Pro-BNP in 16(40%), LDH 8 (20%). Hematological parameters showed leucocytosis 8(20%), leukocytopenia 4 (10%), thrombocytopenia 12(30%), Deranged coagulation 12(30%), ECHO parameters showed LV dysfunction in 12(30%) of cases, Dilated coronaries 8(20%), PPHN 4(10%) and pericardial effusion 4(10%).
RESPIRATORY SUPPORT :
In early presentation, most neonates required non-invasive ventilation 23(40%), 12(20%) were on ventilator as primary support, 6(10%) on Nasal Oxygen.
In late MIS-N, respiratory support requirement was low, Noninvasive 4(10%) compared to Early MIS-N neonates, 4 (10%) on ventilator, nasal oxygen support 8(20%).