Primary outcome
LISA (n=75)
InSURE (n=75) RR (95% CI)
P-value
Intubation within 72h of birth, n (%)
30(40%)
30(40%)
1.0 (0.68 to 1.48)
>0.99***
Secondary outcomes (Major complications) n (%) CT
IVH
07
09
0.9418 (0.49 – 1.50)
>0.99***
BPD
06
09
0.85 (0.41 – 1.43)
0.79***
hsPDA
28
30
1.07 (0.75 – 1.47)
0.74***
NEC
03
04
0.92 (0.33 – 1.68)
>0.99***
Pneumothorax
01
02
0.50 (0.04 – 5.40)
0.99***
LOS
27
30
1.038 (0.72 – 1.43)
0.87***
ROP
08
10
0.96 (0.51 – 1.49)
>0.99***
Median (IQR) duration of MV (days)
6.5 (5.5-7) 6.25 (5.5-7)
0.40#
Median (IQR) duration of non-invasive respiratory support (days)
6 (5-6)
6(5.25-6.5)
0.50#
Median (IQR) Duration of Supplemental Oxygen 5(3-11) 5(3-14) 0.90#
Repeat dose of surfactant, n (%)
13 (17.33%)
11 (14.66%)
0.82**
Adverse events during surfactant administration
Transient desaturation/ bradycardia), n (%) 9 (12%) 11 (14.66%) 0.63**
Regurgitation, n (%) 4 (5.33%) 3 (4%) 0.69**
Median (IQR) length of hospital stay (days)
30.5(22-39)
26 (18.5-41)
0.56#
Survival n (%)
54 (72%)
52 (69.33%)
1.07 (0.76 -1.57)
0.86***