What is Already Known about this Subject
Opioid-induced hyperalgesia is highly prevalent in surgery patients,
contributing to many undesirable events, such as more severe
postoperative pain, extra opioids demand, high incidence of side
effects, etc.
Multiple medications with different kinds of mechanisms were proved to
prevent the increase in postoperative pain caused by OIH in clinical
routines. However, the comparative effects of different kinds of
pharmacologic interventions are urgently needed for a better guideline
for individualized anesthesia protocol.