W. Jaksch 2002 |
Austria |
Austria |
Austria |
15/15 |
15/15 |
31.5 |
NA |
S(+)-ketamine 0. 5 mg/kg IV + 2.0 μg/kg· min continuous infusion |
arthroscopic anterior cruciate ligament repair |
Remifentanil 0.125-1.0
μg/kg· min |
B. Guignard
2002
|
France
|
France
|
France
|
25/25
|
14/16
|
62.5
|
9/35/7
|
ketamine 0. 15 mg/kg IV + 2.0 μg/kg· min continuous infusion
|
open colorectal surgery
|
Remifentanil 0.25 μg/kg· min
|
A. Sahin
2004
|
Turkey
|
Turkey
|
Turkey
|
17/16
|
16/17
|
47.4
|
NA
|
ketamine 0. 5 mg/kg IV
|
Lumbar disk operation
|
Remifentanil 0.1 μg/kg· min
|
A. C. Van Elstraete 2004 |
France |
France |
France |
20/20 |
20/20 |
29.0 |
NA |
ketamine 0. 5 mg/kg IV + 2.0 μg/kg· min continuous infusion |
elective electrodissection tonsillectomy |
Remifentanil 0.125-1.0
μg/kg· min |
D. G. Snijdelaar 2004 |
Canada |
Canada |
Canada |
11/10 |
21/0 |
60.0 |
8/12/1 |
amantadine 200mg orally at night and at 1h before surgery and
100mg at 8, 20, and 32 h after surgery |
radical prostatectomy |
NA |
V. Joly
2005
|
France
|
France
|
France
|
24/25
|
18/32
|
57.5
|
21/22/7
|
ketamine 0. 5 mg/kg IV + 5.0 μg/kg· min continuous infusion+ 2.0 μg/kg·
min for 48h after surgery
|
abdominal surgery
|
Remifentanil 0.4 μg/kg· min
|
J. H. Ryu
2008
|
Korea
|
Korea
|
Korea
|
25/25
|
0/50
|
42.4
|
37/13/0
|
magnesium sulphate 50 mg/kg IV + 15 mg/kg· h continuous infusion
|
total abdominal hysterectomy
|
Remifentanil TCI 4 ng/ml
|
S. Kaya
2009
|
Turkey
|
Turkey
|
Turkey
|
20/20
|
NA
|
50
|
NA
|
magnesium sulphate 30 mg/kg IV + 500 mg/ h continuous infusion
|
elective abdominal hysterectomy
|
Remifentanil 0.25 μg/kg· min
|
H. R. Jo
2011
|
Korea
|
Korea
|
Korea
|
20/20
|
0/40
|
46.1
|
34/6/0
|
pregabalin 150 mg orally
|
non-malignant total abdominal hysterectomy
|
Remifentanil TCI 3-4 ng/ml
|
C. Lee
2011
|
Korea
|
Korea
|
Korea
|
25/25
|
50/0
|
63.4
|
NA
|
magnesium sulfate 80 mg/kg IV
|
robot-assisted laparoscopic prostatectomy
|
Remifentanil 0.3 μg/kg· min
|
C. Lee*
2011
|
Korea
|
Korea
|
Korea
|
30/30
|
38/22
|
38.2
|
NA
|
adenosine 80 μg/kg· min continuous infusion
|
tonsillectomy
|
Remifentanil 0.1 μg/kg· min
|
J. W. Song
2011
|
Korea
|
Korea
|
Korea
|
28/28
|
11/45
|
46.0
|
NA
|
magnesium sulphate 30 mg/kg IV + 10 mg/kg· h continuous infusion
|
thyroidectomy
|
Remifentanil 0.2 μg/kg· min
|
H. Bornemann-Cimenti
2012
|
Germany
|
Germany
|
Germany
|
13/13
|
11/15
|
56.9
|
NA
|
pregabalin 300 mg orally
|
elective transperitoneal nephrectomy
|
Remifentanil 0.1~0.5 μg/kg· min
|
C. Lee
2013
|
Korea
|
Korea
|
Korea
|
28/29
|
0/57
|
48.7
|
NA
|
dexmedetomidine 1.0 μg/kg IV + 0.7 μg/kg· h continuous infusion
|
laparoscopically assisted vaginal hysterectomy
|
Remifentanil 0.3 μg/kg· min
|
C. Lee*
2013
|
Korea
|
Korea
|
Korea
|
31/29
|
31/29
|
50.7
|
NA
|
pregabalin 300 mg orally
|
laparoendoscopic single-site urologic surgery
|
Remifentanil 0.3 μg/kg· min
|
S. Treskatsch
2014
|
Germany
|
Germany
|
Germany
|
16/17
|
8/25
|
66
|
NA
|
amantadine 200 mg/500 ml solution
|
intra-abdominal surgery
|
Remifentanil 0.2 μg/kg· min
|
E. Choi
2015
|
Korea
|
Korea
|
Korea
|
25/25
|
0/50
|
44.1
|
NA
|
ketamine 0. 5 mg/kg IV + 5.0 μg/kg· min continuous infusion
|
elective laparoscopic gynecological surgery
|
Remifentanil 0.3 μg/kg· min
|
P. C. Leal
2015
|
Brazil
|
Brazil
|
Brazil
|
28/28
|
9/47
|
44.6
|
28/28/0
|
ketamine 5.0 μg/kg· min continuous infusion
|
Laparoscopic
cholecystectomy
|
Remifentanil 0.4 μg/kg· min
|
H. Bornemann-Cimenti
2016
|
Austria
|
Austria
|
Austria
|
37/19
|
31/25
|
60.5
|
4/24/28
|
S(+)-ketamine 0. 25 mg/kg IV + 0.125 mg/kg· h continuous infusion or
S(+)-ketamine 0.015 mg/kg· h continuous infusion
|
elective major abdominal surgery
|
Remifentanil 0.1-0.3 μg/kg· min
|
M. Kong
2016
|
China
|
China
|
China
|
25/25
|
32/18
|
51.5
|
NA
|
butorphanol 0. 2 μg/kg IV + 0.02 μg/kg· min continuous infusion
|
laparoscopic cholecystectomy
|
Remifentanil 0.3 μg/kg· min
|
C.-H. Koo 2016 |
Korea |
Korea |
Korea |
27/26 |
33/20 |
63.7 |
NA |
ibuprofen 800mg IV over 30 minutes |
pancreaticoduodenectomy |
Remifentanil TCI 4ng/ml |
Z. Yu
2016
|
China
|
China
|
China
|
57/29
|
0/86
|
46.1
|
NA
|
dexmedetomidine 0.5 μg/kg IV + 0.6 μg/kg· h continuous infusion or
flurbiprofen 1.5 mg/kg combination with dexmedetomidine infusion
|
laparoscopic assisted vaginal hysterectomy
|
Remifentanil 0.3 μg/kg· min
|
L. Zhang
2016
|
China
|
China
|
China
|
56/28
|
0/84
|
46.0
|
67/NA/NA
|
butorphanol 20 μg/kg IV or butorphanol 20 μg/kg combined with
flurbiprofen 0.5 mg/kg
|
elective laparoscopic gynaecological surgery
|
Remifentanil 0.3 μg/kg· min
|
C. H. Koo
2017
|
Korea
|
Korea
|
Korea
|
30/31
|
20/41
|
47.0
|
50/11/0
|
naloxone 0.05 μg/kg· min continuous infusion
|
thyroid surgery
|
Remifentanil TCI 4ng/ml
|
M. Mercieri
2017
|
Italy
|
Italy
|
Italy
|
31/32
|
34/29
|
64.5
|
6/42/15
|
buprenorphine 25 μg/h continuous infusion
|
lateral thoracotomy
|
Remifentanil TCI 5ng/ml
|
L. Zhang
2017
|
China
|
China
|
China
|
28/28
|
0/56
|
44.8
|
45/11/0
|
flurbiprofen 1.0 mg/kg IV
|
elective laparoscopic gynecologic surgery
|
Remifentanil 0.3 μg/kg· min
|
H. Qiu
2018
|
China
|
China
|
China
|
32/16
|
24/24
|
NA
|
NA
|
dexmedetomidine 0.2 μg/kg IV or
0.6 μg/kg
|
thyroidectomy
|
Remifentanil 0.2 μg/kg· min
|
B. Sng
2018
|
Singapore
|
Singapore
|
Singapore
|
45/44
|
0/89
|
48.1
|
NA
|
S(+)-ketamine 0. 25 mg/kg IV
|
open abdominal hysterectomy
|
NA
|
X. Du
2019
|
China
|
China
|
China
|
60/20
|
NA
|
NA
|
NA
|
parecoxib 40 mg IV or dexmedetomidine 0.6 μg/kg· h continuous infusion
or both
|
laparoscopic cholecystectomy
|
NA
|
R. Gutiérrez
2019
|
Chile
|
Chile
|
Chile
|
23/24
|
4/43
|
44.5
|
18/29/0
|
ACTZ 250mg IV
|
total thyroidectomy without neck dissection
|
Remifentanil TCI 4.5 ± 0.5ng/ml
|
J. Hu
2020
|
China
|
China
|
China
|
24/24
|
11/37
|
50.2
|
24/24/0
|
nalbuphine 0. 2 mg/kg IV
|
laparoscopic cholecystectomy
|
Remifentanil 0.4 μg/kg· min
|
E. Tognoli
2020
|
Italy
|
Italy
|
Italy
|
24/24
|
29/19
|
58.6
|
19/24/5
|
S(+)-ketamine 5.0 and 2.5 and 2μg/kg· min continuous infusion +
methadone 2.0 mg IV
|
open laparotomy for anterior resection of the rectum
|
Remifentanil TCI 5-7ng/ml
|
Z. Wu
2020
|
China
|
China
|
China
|
60/29
|
28/61
|
40.0
|
74/15/0
|
dexmedetomidine 0.2 μg/kg continuous infusion or 0.5 μg/kg
|
thyroidectomy
|
Remifentanil 0.3 μg/kg· min
|