3.5.3 The time to first postoperative analgesic requirement
A total of 14 studies involved 13 interventions reported the time to first postoperative analgesic requirement (Appendix4 Figure 4.3.1 ). Compared with placebo, flurbiprofen plus dexmedetomidine (MD=43.05, 95% CI: 28.49, 57.60), adenosine (MD=26.90, 95% CI:11.98, 41.82), magnesium sulphate (MD=23.29, 95% CI:12.27, 34.30) and dexmedetomidine (MD=11.39, 95% CI:0.93, 21.84) mean longer time to require first postoperative analgesic (Appendix5 Figure 5.3.2). The league table (Appendix4 Figure 4.3.3 ) illustrates the results of each intervention compared to each other. In the ranking probability plot (Appendix4 Figure 4.3.4 ), flurbiprofen plus dexmedetomidine was ranked highest among 13 interventions whose SUCRA values was 98.5.