What is Already Known about this Subject
Opioid-induced hyperalgesia is highly prevalent in surgery patients, contributing to many undesirable events, such as more severe postoperative pain, extra opioids demand, high incidence of side effects, etc.
Multiple medications with different kinds of mechanisms were proved to prevent the increase in postoperative pain caused by OIH in clinical routines. However, the comparative effects of different kinds of pharmacologic interventions are urgently needed for a better guideline for individualized anesthesia protocol.