Conclusions
In this study, a chromosome-scale genome assembly was reported forS. scabiei , a highly contagious ectoparasite that can affect more
than 100 mammal species. Comparative genome analysis illustrated the
possible mechanisms of scabies mites adapted to a permanent parasitic
life, including metabolism, morphology and detoxification. Whole genome
re-sequencing analysis showed that scabies mites cluster by host species
rather than geographical location, and analysis of their demographic
history supported the view new insights that humans were the primary
hosts of scabies mites, followed by pigs, dogs, and rabbits, but was
inconsistent with the previous hypothesis that humans transmitted
scabies mite according to the domestication time of these hosts. As the
first chromosome-scale genome of mites, S.scabiei genome and
comparative genomics study will provide solid foundation to promote the
study of mites phylogeny and biology, especially for the study of
control strategy for scabies and other mites.