Significant reduction in obstructive episodes by Tenapanor
Treatment with Tenapanor resulted in a significantly lowered number of obstructive episodes in cftr -/- mice (8.3% vs. 46.2%, p<0.05) (Figure 3a), and a significantly better survival of 91.7% with tenapanor compared to 53.9% with vehicle treatment (because all mice with suspected obstruction were sacrificed). In the Cftr +/+ group, survival was 100% both with tenapanor and with vehicle treatment. The site of obstruction was between the proximal and mid colon in most cases, and the segments in which the fecal material had accumulated was mostly restricted to the regions of the mid-distal ileum and the proximal colon (Figure 3b), because obstruction was suspected early. Table 1 shows the age and sex distribution of the obstructed and unobstructedCftr-/- mice. While the total group of mice before gavage had near identical age and sex distributions in both the vehicle and the tenapanor treated groups, the mice that suffered an obstruction had a male and young age predominance.