Significant reduction in obstructive episodes by Tenapanor
Treatment with Tenapanor resulted in a significantly lowered number of
obstructive episodes in cftr -/- mice (8.3% vs.
46.2%, p<0.05) (Figure 3a), and a significantly better
survival of 91.7% with tenapanor compared to 53.9% with vehicle
treatment (because all mice with suspected obstruction were sacrificed).
In the Cftr +/+ group, survival was 100% both
with tenapanor and with vehicle treatment. The site of obstruction was
between the proximal and mid colon in most cases, and the segments in
which the fecal material had accumulated was mostly restricted to the
regions of the mid-distal ileum and the proximal colon (Figure 3b),
because obstruction was suspected early. Table 1 shows the age and sex
distribution of the obstructed and unobstructedCftr-/- mice. While the total group of mice
before gavage had near identical age and sex distributions in both the
vehicle and the tenapanor treated groups, the mice that suffered an
obstruction had a male and young age predominance.