Trend of concomitant psychotropic agents
On the other hand, the rates of concomitant use of anticholinergics, antidepressants, anxiolytics/sleep medications and mood stabilizers in 2021 were 57.4%, 8.2%, 66.1%, and 21.9%, respectively (Table 2). The frequency of anticholinergic use differed over the 20 years (Cochran Q = 261.8, df = 4, p = 1.88x10-55), with a decreasing trend over the past 20 years (χ2 = 133.4, df = 1, p<2.2x10-16) (Table 2). The antidepressants used were also unchanged (Cochran Q = 1.57, df = 4, p = 0.820) (Table 2). The frequencies of anxiolytic and sleeping pill use differed over the 20 years (Cochran Q = 15.2, df = 4, p = 0.04), but without any trend over the 20 years (χ2 = 4.86, df = 1, p = 0.028) (Table 2). The mood stabilizers used differed over the 20 years (Cochran Q = 23.6, df = 4, p = 9.75x10-5), but without any trend over the past 20 years (χ2 = 1.82, df = 1, p = 0.177) (Table 2).