Rapamycin quantity/weighed formulation quantity (Q, mg/g) ± SD
Time (days) 0 2 7 14 21 28 42 56
Ointment 7.21 ± 0.86 7.13 ± 0.28 7.22 ± 0.87 7.59 ± 0.44 10.19 ± 3.44 7.34 ± 0.93 6.64 ± 0.41 6.40 ± 0.16
Emulsion 9.41 ± 0.28 9.29 ± 0.40 9.18 ± 1.04 8.12 ± 0.63 9.48 ± 0.35 11.10 ± 1.94 7.59 ± 0.77 7.87 ± 2.93
Gel 8.40 ± 0.01 7.86 ± 0.10 8.09 ± 1.85 7.80 ± 0.44 7.56 ± 0.19 7.69 ± 0.42 7.71 ± 0.22 8.16 ± 0.23
Liposomes 1.15 ± 0.11 1.17 ± 0.03 1.27 ± 0.13 1.22 ± 0.09 1.24 ± 0.03 1.25 ± 0.07 1.38 ± 0.14 1.22 ± 0.18
Percentage content of remaining rapamycin (%CR) ± SD Percentage content of remaining rapamycin (%CR) ± SD Percentage content of remaining rapamycin (%CR) ± SD Percentage content of remaining rapamycin (%CR) ± SD Percentage content of remaining rapamycin (%CR) ± SD Percentage content of remaining rapamycin (%CR) ± SD Percentage content of remaining rapamycin (%CR) ± SD Percentage content of remaining rapamycin (%CR) ± SD Percentage content of remaining rapamycin (%CR) ± SD
Time (days) 0 2 7 14 21 28 42 56
Ointment 100.00 ± 0.00 99.97 ± 12.81 100.20 ± 4.17 106.82 ± 18.48 139.48 ± 31.38 103.58 ± 24.59 93.47 ± 16.41 89.45 ± 8.67
Emulsion 100.00 ± 0.00 98.89 ± 6.38 97.70 ± 12.17 86.52 ± 9.36 100.80 ± 3.66 118.48 ± 24.34 80.68 ± 7.42 83.85 ± 31.49
Gel 100.00 ± 0.00 93.53 ± 1.15 96.33 ± 21.98 92.82 ± 5.25 89.96 ± 2.20 91.55 ± 5.03 91.79 ± 2.60 97.14 ± 2.70
Liposomes 100.00 ± 0.00 102.65 ± 9.99 111.29 ± 7.43 106.56 ± 2.34 108.58 ± 12.29 110.05 ± 15.94 121.07 ± 11.86 107.51 ± 21.12