Figure 7 Metabolic differences of bioreactor fed-batch HP CHO cells under both constant temperature and temperature downshift cultures. (a) Heat map of differential metabolites between constant temperature and temperature downshift cultures on day 5. (b) KEGG pathway involving the metabolome before and after temperature downshift on day 5. (c) Heat map of differential metabolites before and after temperature downshift on day 8. (d) KEGG pathway involving the metabolome before and after temperature downshift on day 8 (p-value<0.05, top50 according to -log10 p-value).