Figure 9 Effect of constructed biosensors on the shake flask fed-batch process performance of both LP and HP CHO cell lines in fed-batch culture. (●, black) Control group. (■, red) NADPH biosensor. (▲, gray) iNapC biosensor. (◆, blue) SoNar biosensor. (a) LP viable cell density. (b) LP cell viability. (c) HP viable cell density. (d) HP cell viability. (e) LP antibody titer. (f) HP antibody titer. Experimental values represent three biological replicates ± SD.