Discussion
We reported a case of oral Kaposi’s sarcoma associated with HIV
infection and SARS-Cov2.
It is due to HHV-8 infection and is the common malignant skin tumors
associated with HIV infection. Its presence reveals an advanced stage of
the disease [5].
Since covid 19, several studies have demonstrated the action of SARS Cov
2 on the reactivation of the HHV 8 virus hence the increased prevalence
of Kaposi’s sarcoma. They even found that the quality of life of
patients with Kaposi’s sarcoma infected with SARS Cov 2 without HIV
infection is lower than those infected with HIV [1, 6].
A case of an 83-year-old patient was reported for Kaposi’s sarcoma of
the soles of the feet in a patient followed by Covid 19. HIV serology
was tested negative [6].
Cancer is closely related to the risk of severe disease and mortality in
patients with COVID-19. Cov 2 SARS could promote tumor progression and
stimulate metabolic switching in tumor cells to initiate tumor
metabolism with high efficiency. On the other hand, SARS Cov 2 has been
shown to delay the progression of some cancers such as NK and Hodgkin
lymphoma [7]. This may explain the rapid progression of Kaposi’s
sarcoma in our case.