Relationship with the exposure route
As a large-scale valuation of the overall quality of these allergen-symptom relationships obtained, we evaluated whether allergens with a particular exposure route are preferentially linked to symptoms intuitively associated to that entry way. If the allergen-symptom relationships were globally wrong, very generic or totally random, these exposure route–symptom relationships obtained from them neither would present significant p-values nor have biological sense.
The whole list of significant exposure route–symptom relationships (down to a p-value of 0.01) is available as Supplementary Table 2 and represented in Figure 3 .