Acknowledgements

The authors report that no conflicts of interest exist. This study was supported by the fifth batch of technological innovation research projects in Chengdu (2021-YF05 -01331-SN), the Postdoctoral Research and Development Fund of the West China Hospital of Sichuan University (2020HXBH087), and the Short-Term Expert Fund of the West China Hospital (139190032). We also acknowledged the computational supports from the West China Biomedical Big Data Center and the Med-X Center for Informatics of Sichuan University.