INDIVIDUAL CONTRIBUTION
JR and MV conceived and designed this research, drafted the manuscript and approved the final version. WO, JG, WA and FS led the recruitment of patients, helped write and critically revise the manuscript, and approved the final version. JM, AP, JS, and JC helped analyse the data, prepared the figures and table, wrote and critically revised the manuscript and approved the final version. NM, BR, and MN helped recruit patients, critically revised the manuscript, interpreted the data and approved the final version.