Patient characteristics
A total of 682 patients were enrolled in this study. One hundred sixty
patients (138 with hypertensive disorders, eight with caesarean
deliveries, seven with anaemia, six with preterm deliveries, and one
with pyrexia) were excluded (Figure S1). A total of 522
patients were included in the final analysis: 228 (43.7%) with NLA and
294 (56.3%) without NLA. Patients with NLA had a median age of 25.5
years [IQR, 20-28], while patients without NLA had a median age of
23 years (IQR, 21-30); p<0.001). Table 1 displays the clinical
characteristics, interventions, and outcomes of each group. Patients
with NLA had a significantly greater median age, greater frequency of
nulliparity, higher haemoglobin, and less cervical dilation. Most NLA
procedures were performed as an epidural technique (96.1%). There were
no other differences in the other variables between the groups. InTable S1 , we describe the missing data for each variable.
In the NLA group, 31 (13.6%) patients required the administration of
one or more uterotonics. Eighty-seven percent (n =27) required
methylergonovine, 22.6% (n =7) required carbetocin, and 26.2%
(n =5) required misoprostol. A total of 183 patients (80.6%) in
the NLA group received more than two boluses of analgesia. The presence
of PPH was similar between patients with and without NLA.