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\begin{document}

\title{Models and molecular mechanisms for trade-offs in the context of
metabolism}



\author[1]{Seirana Hashemi}%
\author[2]{Roosa Laitinen}%
\author[3]{Zoran Nikoloski}%
\affil[1]{Universität Potsdam}%
\affil[2]{University of Helsinki}%
\affil[3]{Max-Planck-Institut fur molekulare Pflanzenphysiologie}%


\vspace{-1em}



  
  \date{May 16, 2024}


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\begin{abstract}
Accumulating evidence for trade-offs involving metabolic traits has
demonstrated their importance in evolution of organisms. Metabolic
models with different level of complexity have already been considered
when investigating mechanisms that explain various metabolic trade-offs.
Here we provide a systematic review of modelling approaches that have
been used to study and explain trade-offs between: (i) kinetic
properties of individual enzymes, (ii) rates of metabolic reactions,
(iii) rate and yield of metabolic pathways and networks, (iv) different
metabolic objectives in single organisms and in metabolic communities,
and (v) metabolic concentrations. In providing insights into mechanisms
underlying these five types of metabolic trade-offs obtained from
constraint-based metabolic modelling, we emphasize the relation of
metabolic trade-offs to the classical black box Y-model that provides
conceptual explanation for resource acquisition-allocation trade-offs.
In addition, we identify several pressing concerns and offer a
perspective for future research in the identification and manipulation
of metabolic trade-offs by relying on the toolbox provided by
constraint-based metabolic modelling for single organisms and microbial
communities.%
\end{abstract}%



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