What is already known
- ISX9 has been identified as a neurogenesis inducer
- ISX9 could induce differentiation of neuronal, cardiac and islet
endocrine progenitors.What this study adds
- ISX9 is a novel activator of Wnt/β-catenin signaling and targets Axin1
via its N-terminal region.
- ISX9 potentiates the LRP6-Axin1 association and thereby, resulting in
stabilization of
β‐catenin.What is the clinical significance
- ISX9 may be a promising therapeutic agent for alopecia treatment via
upregulating Wnt/β‐catenin signaling