Statistical Analysis
Patients were grouped based upon MTHFR genotype as stated above. With
exception of analysis related to the causal reason for sending MTHFR
genetic testing, patients with wildtype MTHFR results were combined with
those not tested, presuming a majority have wildtype MTHFR, and served
as a control group for analysis. The control group was then compared to
each individual MTHFR genotype. When analyzing the causal reason for
sending of MTHFR genetic testing, those with wildtype MTHFR were solely
utilized as control and compared to each MTHFR genotype. Statistical
comparisons were performed using GraphPad Prism Version 9.3.1 (San
Diego, CA, USA). For comparison of numerical data between control and
each individual MTHFR genotype, Welch’s t-test was applied. For
comparison of categorical data, we utilized Fisher’s exact test.
Significance was defined as p<0.05.