Statistical Analysis
Patients were grouped based upon MTHFR genotype as stated above. With exception of analysis related to the causal reason for sending MTHFR genetic testing, patients with wildtype MTHFR results were combined with those not tested, presuming a majority have wildtype MTHFR, and served as a control group for analysis. The control group was then compared to each individual MTHFR genotype. When analyzing the causal reason for sending of MTHFR genetic testing, those with wildtype MTHFR were solely utilized as control and compared to each MTHFR genotype. Statistical comparisons were performed using GraphPad Prism Version 9.3.1 (San Diego, CA, USA). For comparison of numerical data between control and each individual MTHFR genotype, Welch’s t-test was applied. For comparison of categorical data, we utilized Fisher’s exact test. Significance was defined as p<0.05.