MTHFR variants 677TT and 677CT/1298AC are associated with
decreased tolerance to methotrexate in pediatric acute lymphoblastic
leukemia
Connor P. Hall1, Sarah G. Poggi1,
Ghislaine A. Cedeno1, and Stacy L.
Cooper1
1Division of Pediatric Oncology, Johns Hopkins
University School of Medicine, Baltimore, Maryland, USA
Correspondence: Stacy L. Cooper, MD
Johns Hopkins University
Bloomberg Children’s Center
1800 Orleans St.
Baltimore, Maryland 21231
Phone: 410-955-8751; Fax: 410-955-0028
Email: scoope30@jhmi.edu
Word Count:
Abstract: 244
Manuscript: 2845
Number of Figures/Tables: 5
Running Title: MTHFR decreases tolerance to Methotrexate in ALL
Key Words: acute lymphoblastic leukemia/ ALL/ MTHFR/ Methotrexate/
Maintenance Therapy
Note: Results previously presented as “MTHFR polymorphisms are
associated with decreased methotrexate tolerance in pediatric ALL” at
the ASPHO annual meeting on May 5, 2022 and published in Pediatric Blood
and Cancer.
Abbreviations: