Organ supportive therapies and complications
Organ supportive therapies including invasive mechanical ventilation
(88% vs. 53%, p=0.001) and vasoactive support (75% vs. 46%, p=0.03)
were required more commonly in patients with IAPA than those without
(table 3). Median duration of mechanical ventilation was significantly
longer in IAPA patients (14 [interquartile range (IQR): 11, 20] days
vs. 2 [IQR: 0, 9] days, p≤0.001) but not extended in asthmatic
patients (0 vs. 2 days in influenza patients with and without asthma and
15 vs. 11 days in IAPA patients with and without asthma, p=0.4).
Complications were common in all patients with influenza infection but
more common in IAPA patients, such as acute respiratory distress
syndrome18, 19 (ARDS, 53% vs. 26%, p=0.04) and
bacterial respiratory infection (65% vs. 37%, p=0.04). IAPA patients
had higher ICU-mortality (35% vs. 16.4%, p=0.05) and more frequently
poor outcomes (94% vs. 46%, p<0.001).