*If critically ill and unstable patient with suitable clinical
presentation of IAPA start preemptive therapy before microbiological
results are obtained. Determine GM before starting antifungal treatment
because of rapid decrease under therapy. Determine voriconazole trough
level after 5-7d (aim at 1-5 mg/l). Alternative treatment: liposomal
amphotericin B. IAPA = influenza-associated pulmonary aspergillosis, BAL
= bronchoalveolar lavage, TS = tracheal secretion.
Figure 2: Predictors for IAPA (A) and combined poor outcome (B)