Organ supportive therapies and complications
Organ supportive therapies including invasive mechanical ventilation (88% vs. 53%, p=0.001) and vasoactive support (75% vs. 46%, p=0.03) were required more commonly in patients with IAPA than those without (table 3). Median duration of mechanical ventilation was significantly longer in IAPA patients (14 [interquartile range (IQR): 11, 20] days vs. 2 [IQR: 0, 9] days, p≤0.001) but not extended in asthmatic patients (0 vs. 2 days in influenza patients with and without asthma and 15 vs. 11 days in IAPA patients with and without asthma, p=0.4). Complications were common in all patients with influenza infection but more common in IAPA patients, such as acute respiratory distress syndrome18, 19 (ARDS, 53% vs. 26%, p=0.04) and bacterial respiratory infection (65% vs. 37%, p=0.04). IAPA patients had higher ICU-mortality (35% vs. 16.4%, p=0.05) and more frequently poor outcomes (94% vs. 46%, p<0.001).