Functional Consequence and Therapeutic Targeting of
Cryptic ALK Fusions (ALKfus) in Monosomy7 AML
Makia K. Manselle 1, 2, Rhonda E.
Ries1, MA Tiffany Hylkema1, Amanda
Leonti1, MS, Danielle C. Kirkey, MD1,
2 Scott N. Furlan, MD1, and Soheil Meshinchi, MD,
PhD1, 2
1 - Fred Hutchinson Cancer Center, Seattle, WA
2 - University of Washington, Seattle, WA
Correspondence to:
Makia Manselle
Fred Hutchinson Cancer Center
1100 Fairview Ave N, D2-345
Seattle, WA, 98109
(206) 667- 6474
mmansell@fredhutch.org
Text word count: 1152
Abstract word count: 95
Running Title: “Targeting Cryptic ALK fusions in
Mono7”
Key words: AML, Cancer Genetics, Chemotherapy, Cytogenetics,
Hematology/Oncology
Figures included: 2
Tables: 1