Main Findings
We performed a single-center, retrospective review of 307 patients treated with amiodarone for a minimum of one month as a part of a rhythm-control strategy that culminated in catheter ablation for AF. We hypothesized that failure of rhythm control on amiodarone would predict increased rates of AF recurrence following ablation, but found that our hypothesis was incorrect; patients who did and did not achieve rhythm control on amiodarone prior to PVI had equivalent rates of freedom from recurrent atrial arrhythmia following ablation, suggesting that response to amiodarone is not an adequate litmus test for considering PVI in AF patients.