Conclusion
The AMES presents in childhood, typically with high blood pressure,
hypokalemia, and low renin and aldosterone levels. The hallmark of the
syndrome is increased cortisol-to-cortisone metabolites in the urine.
Spironolactone, which blocks receptors of cortisol and aldosterone, was
adopted. Adjunctive treatments are supplementation with potassium and a
diet with low sodium. Cortisol formation can be suppressed through ACTH
feedback inhibition using dexamethasone, but a consistent
antihypertensive effect is not guaranteed and has significant long-term
adverse events. To prevent or improve end-organ damage (EOD) morbidity,
diagnosis then treatment should be early.