Conclusion
The AMES presents in childhood, typically with high blood pressure, hypokalemia, and low renin and aldosterone levels. The hallmark of the syndrome is increased cortisol-to-cortisone metabolites in the urine. Spironolactone, which blocks receptors of cortisol and aldosterone, was adopted. Adjunctive treatments are supplementation with potassium and a diet with low sodium. Cortisol formation can be suppressed through ACTH feedback inhibition using dexamethasone, but a consistent antihypertensive effect is not guaranteed and has significant long-term adverse events. To prevent or improve end-organ damage (EOD) morbidity, diagnosis then treatment should be early.