Conclusions
We have delineated one aspect of the perinatal pathophysiology of adenomyosis that can cause pain in more than one of eight pregnancies with adenomyosis, which may be associated with an increased incidence of PE resulting in preterm delivery. The risk of adverse perinatal outcomes in a patient population with adenomyosis is not well known, but our findings have provided new insights, indicating that those who develop adenomyosis pain during pregnancy, especially those with high CRP levels, may be at high risk for the later development of PE and consequently warrant special attention in perinatal care.