Hematopathologic Characteristics
Thirty-eight of the 57 patients had flow cytometry performed on their LN samples, and all were negative for malignancy by immunophenotyping. This included three patients who had concurrent diagnoses of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). Two of these three had PTGC in one biopsied LN with NLPHL present in a different excised LN, while the third had both NLPHL and PTGC present in the same LN concurrently. Two of the 38 patients who had flow cytometry performed on their LN samples had elevated percentages of double negative T-cells, concerning for autoimmune lymphoproliferative syndrome (ALPS).