Conclusion
In conclusion, the most frequent medicine change was discontinuation due
to lack of indication and most of the discontinued medicines were
medicines that may cause adverse effects in older patients. A higher
number of medicines, higher sedative and higher anticholinergic burden
of the medicines, if the patient was motivated for medicine changes or
had a prescription of metoclopramide, an iron preparation, other
antidepressant (i.e. not selective serotonin reuptake inhibitors),
non-steroid anti-inflammatory drug, or drug for urinary frequency and
incontinence was associated with a higher number of overprescribed
medicines. These patient- and medication-related factors could aid in
identifying patients that will benefit most from medication reviews.