We analyze 20 years (2001-2020) of temperature and salinity profiles at the LTER-MC coastal station in the Gulf of Naples, Mediterranean Sea. Surface and bottom layer show increases of temperature (+0.01 and +0.03°C/year, 2005-2019); water-columns budgets (heat, freshwater) show pseudo-periodic oscillations every 3 to 5 years, and weak linear trends. Seasonal minimum of salinity occurs two months later than the runoff peak, pointing to the importance of horizontal circulation in regulating the inshore-offshore exchanges and the residence time of freshwater contribution. Inter-annual variations of the mixed layer depth (MLD) exhibit a shallowing (-1.27m/year during winter) and a shortened time span of the fully mixed water-column. A visible decadal shift in the external forcings suggests an influence of winterly wind stress in 2010-2019, that prevailed over dominant buoyancy fluxes in 2001-2009. Changes are visible in the large-scale indices of the North Atlantic and Western Mediterranean Oscillations and highlight the role of wind direction, offshore or inshore oriented, in disrupting the stratification driven by freshwater runoff. A random forest regression confirms that role and quantifies the MLD drivers importances. This allows for a reliable prediction of the stratification using external variables independent from the in situ observations.