Radiation-topography interaction plays an important role in the surface energy balance over the Tibetan Plateau (TP). However, the impacts of such interaction over the TP on climate locally and in the Asian regions remain unclear. This study uses the Energy Exascale Earth System Model (E3SM) to evaluate the regional and teleconnected impacts of radiation-topography interaction over the TP. Land-atmosphere coupled experiments show that topography regulates the surface energy balance, snow processes, and surface climate over the TP across seasons. Accounting for radiation-topography interaction overall improves E3SM’s performance in simulating surface climate. The winter cold bias in air temperature decreases from -4.48 K to -3.70 K, and the wet bias in summer precipitation is mitigated in southern TP. The TP’s radiation-topography interaction further reduces the South and East Asian summer precipitation biases. Our results demonstrate the topographic roles in regional climate over the TP and highlight its teleconnected climate impacts.