Pharmacokinetic Analyses
PK analysis of plasma concentration-time curves was performed using a non-atrial model using WinNonlin version 8.2 software, and the pharmacokinetic parameters of nifedipine were calculated based on the concentration of nifedipine. After Tmax, they were treated as missing. The linear trapezoidal method was used to calculate the area under the blood concentration-time curve (AUC) AUC0-t from time 0 to t. AUC0-∞ was calculated as the ratio of the sum of AUC0-t and the last measurable concentration to the elimination rate constant. Cmax and time to peak Tmax were obtained directly from the individual plasma concentration-time curve. The terminal elimination half-life (t1/2) was calculated as t1/2 = 0.693 / elimination rate constant, where 0.693 was derived from ln2.