Statistical Analyses
The main pharmacokinetic parameters of nifedipine, Cmax, AUC0-t, and AUC0-∞, were log-transformed and subjected to analysis of variance (ANOVA). The ANOVA model had dosing order, formulation, and period as fixed effects, formulation factors for different subjects as random effects, and the within-subject formulation repeated measures (i.e., repeated doses of subject formulation T, reference formulation R) effects were considered. The within-subject standard deviation SWR, point estimates of the geometric mean ratio, the upper limit of the 90% confidence interval, and the one-sided 95% confidence interval of the geometric mean ratio (subject formulation/reference formulation) were calculated for the main indicators. The results of the double one-sided t-test are also presented.