Pharmacokinetic Analyses
PK analysis of plasma concentration-time curves was performed using a
non-atrial model using WinNonlin version 8.2 software, and the
pharmacokinetic parameters of nifedipine were calculated based on the
concentration of nifedipine. After Tmax, they were
treated as missing. The linear trapezoidal method was used to calculate
the area under the blood concentration-time curve (AUC)
AUC0-t from time 0 to t. AUC0-∞ was
calculated as the ratio of the sum of AUC0-t and the
last measurable concentration to the elimination rate constant.
Cmax and time to peak Tmax were obtained
directly from the individual plasma concentration-time curve. The
terminal elimination half-life (t1/2) was calculated as
t1/2 = 0.693 / elimination rate constant, where 0.693
was derived from ln2.