Deformation within the Indo-Asian Collision Zone is accommodated on a complex network of faults spanning thousands of kilometers in any direction. In order to characterize faulting in the orogen for seismic hazard assessment, a new fault database was compiled, resulting in ~1000 fault traces mapped at around 1:100,000. A block model was created simultaneously with the fault mapping to estimate robust, internally-consistent slip rates on all mapped faults. The block model inverts >3000 GNSS velocities and ~200 Quaternary geologic slip rates. The results yield slip rates that are generally quite consistent with geologic estimates, indicating that decadal and millenial-scale deformation rates are compatible. Additionally, the great strike-slip faults of the orogen are the dominant faults of the orogen’s interior, accumulating and redistributing slip from linked, subordinate fault networks in a way similar to transfer faults within a basin or thrust belt, but on much larger scale.