CD40-CD40L and ICOS-ICOSL expression are markedly increased in nasal polyp tissue of ECRS patients
Representative staining of CD40, CD40L, ICOS, and ICOSL on sections from the nasal tissue involved in this study, which varied in density and intensity in patients with ECRS and Non-eCRS (Fig. 1A). The expression levels of CD40 (64.67 ± 13.48 vs 13.12 ± 2.52, p=0.0001), ICOS (63.85 ± 16.8 vs 7.05 ± 2.31, p=0.0039), and ICOSL (81.36 ± 15.88 vs 14.72 ± 2.00, p<0.0001) were significantly higher in the nasal tissue of ECRS patients compared with that in patients of Non-eCRS (Fig. 1B). And the number of CD40L positive cells was also increased in ECRS nasal tissue compared with that in the nasal polyps of Non-eCRS patients, although there was no significant difference (Fig. 1B).