CD40-CD40L and ICOS-ICOSL expression are strongly correlated in nasal tissue of edematous pattern CRS patients
Additionally, we further found a strong positive correlation between the expression of CD40-CD40L and ICOS-ICOSL in nasal polyps of edematous pattern CRS patients. To be specific, there was a significantly positive correlation between ICOS and CD40 expression (r=0.8966, p<0.0001, Fig. 4A), ICOSL and CD40 expression (r=0.6679, p=0.0080, Fig. 4B), CD40L and CD40 expression (r=0.5429, p=0.0391, Fig. 4C), ICOS and CD40L expression (r=0.6300, p=0.0238, Fig. 4D), ICOSL and CD40L expression (r=0.8286, p=0.0003, Fig. 4E), as well as ICOSL and ICOS expression (r=0.8611, p=0.0003, Fig. 4F).