CD40-CD40L and ICOS-ICOSL expression are markedly increased in
nasal polyp tissue of ECRS patients
Representative staining of CD40, CD40L, ICOS, and ICOSL on sections from
the nasal tissue involved in this study, which varied in density and
intensity in patients with ECRS and Non-eCRS (Fig. 1A). The expression
levels of CD40 (64.67 ± 13.48 vs 13.12 ± 2.52, p=0.0001), ICOS (63.85 ±
16.8 vs 7.05 ± 2.31, p=0.0039), and ICOSL (81.36 ± 15.88 vs 14.72 ±
2.00, p<0.0001) were significantly higher in the nasal tissue
of ECRS patients compared with that in patients of Non-eCRS (Fig. 1B).
And the number of CD40L positive cells was also increased in ECRS nasal
tissue compared with that in the nasal polyps of Non-eCRS patients,
although there was no significant difference (Fig. 1B).