<div>
<b>Background:</b> Killer-cell immunoglobulin-like receptors 2DL4 (
<i>KIR2DL4</i>) and the human leukocyte antigen class I-G (
<i>HLA-G</i>) display vital parts in immune responses against HCV
infection. We select four potentially functional SNPs of KIR/HLA to
explore the associations between <i>KIR2DL4/HLA-G</i> genetic variants
and HCV infection results. <b>Methods:</b> In the present case-control
investigation, <i>KIR2DL4</i>-rs660773， <i>KIR2DL4</i>-rs660437，
<i>HLA-G</i>-rs9380142, and <i>HLA-G</i>-rs1707 SNPs were sorted as
genotype in a total of 2225 high-risk subjects, involving 1778 paid
blood donors and 447 drug users. The SNPs were functionally annotated
using bioinformatics analysis. <b>Results:</b> Following adjusting by
age, sex, ALT, AST, <i>IFNL4</i>-rs12979860, <i>IFNL4</i>-rs8099917, and
the infection route, the logistic regression analysis (LRA) discovered
that <i>KIR2DL4</i>-rs660773 and <i>HLA-G</i>-rs9380142 were correlated
with vulnerability to HCV infection (all <i>P</i> &lt;0.05). In a
locus-dosage way, compared with subjects carrying the rs9380142-AA or
rs660773-AA genotypes, subjects with rs9380142-AG or rs660773-AG/GG (all
<i>P</i> &lt;0.05) were more vulnerable to HCV infection; the
overall impact of their risk genotypes (rs9380142-AGrs660773-AG/GG) was
correlated with an elevated incidence of HCV infection (
<i>P<sub>trend</sub></i>&lt;0.001). In the Haplotype
analysis, patients with haplotype AG were more likely to contract HCV
compared to those with the highest common AA haplotype ( <i>P</i>=
0.002) were higher in susceptibility to infect HCV.nThe SNPinfo web
server estimated that rs660773 is a transcription factor binding site
(TFBS), whereas rs9380142 is a potential microRNA-binding site.
<b>Conclusion:</b> In the Chinese high-risk population, KIR2DL4
rs660773 and HLA-G rs9380142 polymorphisms are related to HCV
susceptibility <i>.</i>
</div>