ABSTRACT
Paraneoplastic neurologic
syndromes (PNS) are rare in pediatrics and are understood to be
consequences of cross-reactivity against various neuroendocrine antigens
expressed on cancer cells. Here, we report a case of autoimmune
encephalitis, a type of paraneoplastic neurologic syndrome that was
associated with a case of adrenocortical carcinoma and had some clinical
response to immunosuppressive therapy. Adrenocortical carcinoma is a
rare tumor with controversial tissue of origin but expresses various
neuroendocrine antigens that could be the possible mechanism for this
rare yet interesting association.