Table 2.Comparison in study parameters among healthy controls and CKD subgroups (i.e. <60 vs ≥60 years old) using One-way ANOVA (post-hoc analysis Bonferroni).
Controls, n=30 CKD patients, n=60 CKD patients, n=60 P value* P value† P value††
<60 years, n=25 ≥60 years, n=35
Age, years 47±5 49±7 68±5 0.748 <0.001 <0.001
Male gender, n (%) 20 (67) 18 (72) 24 (69) 0.773 1.000 1.000
BMI, kg/m2 26.3±2.5 27.3±4.9 26.9±5.1 1.000 1.000 1.000
Systolic BP, mmHg 125±17 130±18 143±21 1.000 0.023 0.001
Diastolic BP, mmHg 75±10 74±11 78±11 1.000 0.612 0.820
LVMI, g/m2 89.6±21.2 114.7±41.1 113.4±34.2 0.017 1.000 0.013
LAVI, ml/m2 26.4±5.2 28.9±7.7 31.8±10.6 0.819 0.555 0.032
LVEF, % 66±7 65±8 68±7 1.000 0.301 0.751
E/A 1.14±0.31 1.03±0.33 0.80±0.19 0.504 0.007 <0.001
Sm, cm/s 8.7±1.7 8.6±2.5 8.0±1.6 1.000 0.626 0.507
Sl, cm/s 11.3±2.5 10.7±2.9 9.5±2.3 1.000 0.211 0.019
E’, cm/s 12.3±2.9 10.6±2.6 8.5±1.8 0.045 0.003 <0.001
E/E’ 6.06±1.37 7.80±2.71 8.50±2.59 0.019 0.755 <0.001
RWT 0.40±0.06 0.47±0.08 0.49±0.11 0.031 1.000 0.001
GLS, % -21.1±3.3 -20.3±3.3 -20.6±3.0 1.000 1.000 1.000
TWIST, degrees 9.39±4.05 7.60±4.69 8.45±4.21 0.392 1.000 1.000
UNTWIST, degrees/s -69.0±28.1 -60.9±29.9 -75.7±28.9 0.917 0.177 1.000
Data are presented as number of patients (%) or mean ± standard deviation. BMI, Body mass index; BP, Blood pressure; CKD, Chronic kidney disease; GLS, Global longitudinal strain; LAVI, Left atrial volume index; LVEF, Left ventricular ejection fraction; LVMI, Left ventricular mass index; RWT, Relative wall thickness. *Healthy controls vs younger CKD patients, †Older vs Younger CKD patients, ††Healthy controls vs older CKD patients Data are presented as number of patients (%) or mean ± standard deviation. BMI, Body mass index; BP, Blood pressure; CKD, Chronic kidney disease; GLS, Global longitudinal strain; LAVI, Left atrial volume index; LVEF, Left ventricular ejection fraction; LVMI, Left ventricular mass index; RWT, Relative wall thickness. *Healthy controls vs younger CKD patients, †Older vs Younger CKD patients, ††Healthy controls vs older CKD patients Data are presented as number of patients (%) or mean ± standard deviation. BMI, Body mass index; BP, Blood pressure; CKD, Chronic kidney disease; GLS, Global longitudinal strain; LAVI, Left atrial volume index; LVEF, Left ventricular ejection fraction; LVMI, Left ventricular mass index; RWT, Relative wall thickness. *Healthy controls vs younger CKD patients, †Older vs Younger CKD patients, ††Healthy controls vs older CKD patients Data are presented as number of patients (%) or mean ± standard deviation. BMI, Body mass index; BP, Blood pressure; CKD, Chronic kidney disease; GLS, Global longitudinal strain; LAVI, Left atrial volume index; LVEF, Left ventricular ejection fraction; LVMI, Left ventricular mass index; RWT, Relative wall thickness. *Healthy controls vs younger CKD patients, †Older vs Younger CKD patients, ††Healthy controls vs older CKD patients Data are presented as number of patients (%) or mean ± standard deviation. BMI, Body mass index; BP, Blood pressure; CKD, Chronic kidney disease; GLS, Global longitudinal strain; LAVI, Left atrial volume index; LVEF, Left ventricular ejection fraction; LVMI, Left ventricular mass index; RWT, Relative wall thickness. *Healthy controls vs younger CKD patients, †Older vs Younger CKD patients, ††Healthy controls vs older CKD patients Data are presented as number of patients (%) or mean ± standard deviation. BMI, Body mass index; BP, Blood pressure; CKD, Chronic kidney disease; GLS, Global longitudinal strain; LAVI, Left atrial volume index; LVEF, Left ventricular ejection fraction; LVMI, Left ventricular mass index; RWT, Relative wall thickness. *Healthy controls vs younger CKD patients, †Older vs Younger CKD patients, ††Healthy controls vs older CKD patients Data are presented as number of patients (%) or mean ± standard deviation. BMI, Body mass index; BP, Blood pressure; CKD, Chronic kidney disease; GLS, Global longitudinal strain; LAVI, Left atrial volume index; LVEF, Left ventricular ejection fraction; LVMI, Left ventricular mass index; RWT, Relative wall thickness. *Healthy controls vs younger CKD patients, †Older vs Younger CKD patients, ††Healthy controls vs older CKD patients