Introduction
Epstein-Barr virus was first discovered 50 years ago through its association with Burkitt’s lymphoma, and as seen, the virus encodes a set of products that have been found to have an interaction or similarity between them and a wide range of Anti-apoptotic molecules, cytokines may promote immortalization in cells and transformation.1-3 The delayed infection hypothesis proposed by Greaves also suggests that late exposure to infectious agents, as opposed to early exposure, can lead to an abnormal immune response that by an indirect mechanism can increase leukogenesis and acute lymphocytic leukemia.4
Lymphoma is divided into two categories: Hodgkin’s and non-Hodgkin’s. The most common site of NHL lymph node proliferation is the gastrointestinal tract, which accounts for 15 to 20 percent of all cases.5
Obstructive jaundice is one of the manifestations of malignancies that is usually caused by external compression of the common bile duct, but many cases of malignant infiltration of the internal bile duct have not been reported. Acute lymphoblastic leukemia (ALL), which is a clonal hematologic disorder and is known as non-Hodgkin’s lymphoma, also has symptoms such as fever and fatigue and thrombocytopenia and hepatomegaly. However, there are limited reports of liver failure and jaundice as early manifestations of the disease.6-10
Here we look at a case that presents with symptoms of jaundice and lymphadenopathy and is known in tests for Epstein-Barr virus to cause acute lymphoblastic leukemia in this patient.