It was found that 6 /11 (54.5%) subjects did not report any adverse outcomes and were uneventful pregnancies. There were 2 miscarriages. Adverse events reported were consistent with background population expectation, including: 1 postpartum hemorrhage, 1 case of preeclampsia, 1 preterm birth, 2 NICU admissions, and 2 caesarean sections. None of the subjects gave birth to low birthweight (bwt) infants (Table 3A). Overall, birthweights for gestational age (GA) fell between the 10th and 90th percentiles (%ile), so all subjects in the Prazosin cohort exhibited fetal growth within the normal population distribution. Looking at individual patient data as shown in Table 3B, patient 1 experienced hemorrhaging (9.1%) and required NICU (18.2%), patient 3 required a c-section (18.2%), patients 4 and 7 experienced a miscarriage (18.2%), and patient 9 experienced pre-eclampsia (9.1%), required a c-section (18.2%), required NICU (18.2%), and had a preterm baby (9.1%).
When the patients were asked about Pregnancy satisfaction, 8/11 (72.7%) reported that they were satisfied and thought their pregnancies had gone as smoothly as possible.