3.4 Comparison of the clinical characteristics of the AGE
patients infected with HAdV-F and non HAdV-F (Subgroup A, B, C, D,
untypeable penton) adenoviruses
Mean Vesikari score of the patients infected with different subgroups A
(n=11, 11.82 ± 2.56), B (n=5, 10.20 ± 1.30) C (n=7, 11.71 ± 2.360) and D
(n= 2, 12.0 ± 1.41) and F (n=32; 12.2± 2.35)) as well as comparison of
HAdV-F versus non-HAdV-F strains (n=29; 11.48 ± 2.41) showed no
significant difference (Table 5, p >0.05). There was no
significant difference in the mean number of days, mean number of
episodes per 24 hr. of diarrhea and vomiting as well as the body
temperature of the patients among these groups (Table 5).
The AGE patients infected with only HAdV-F (n=28, cases with
co-infection of RVA or NoV were omitted from the analysis) and only
non-HAdV-F strains (n=21) showed 18 (64.2%) and 13 (61.9%) patients
with high body temperature and 25 (89.3%) and 15 (71.4%) with a
clinical history of vomiting respectively. These proportions were not
significantly different from each other (p=0.864; p = 0.110
respectively). Similar comparison for <5% and
>5% degree of dehydration (HAdV-F: 78.6% (22/28), non
HAdV-F: 79.2% (16/21); p = 0.843), and severe and very severe disease
outcome (HAdV-F: 82% (23/28), non HAdV-F: 57% (12/21); p = 0.055)
showed no significant difference. The number of days and number of
episodes in 24 hrs duration of diarrhea ranged between 1-5 days (Median
3) and 4-25 episodes (Median 10) for HAdV-F and 1-4 days (Median 3) and
4-20 episodes (Median 7) for non-HAdV-F patients. Analysis of the
vomiting days and episodes indicated 0-4 days (median 2), and 0-20
episodes (median 4) in HAdV-F and 0-4 days (median 1) and 0-8 episodes
(median 3) in non-HAdV-F patients.
Each group of patients, with only HAdV-A (n=8), HAdV-B (n=5), HAdV-C
(n=5), HAdV-D(n=1), and penton untypeable (n=2) adenovirus infection was
compared for clinical characteristics with HAdV-F (n=28) strains. No
significant difference for the percentage of patients with high body
temperature, 5% or more dehydration and severe disease outcome was
observed with a single exception. In the case of subgroup B infections
significantly low number of cases with severe disease outcome (40.0%)
were observed as compared to subgroup F infections (82.1%) (p = 0.043).
Comparison of the clinical characteristics of the patients infected with
HAdV-40 (n=13) and HAdV-41(n=16) with each other showed no significant
difference. The vomiting episodes per 24 hr. ranged between 0-20 (Median
4) for HAdV-40 patients and 0-5 (Median 3) for HAdV-41 patients.
Mixed infection of HAdV (Subgroup F, n=3; Subgroup A, n=1; Subgroup D,
n=1, non-typable , n=2) and RVA (G1P[8], n=5; G2P[4], n=1;
G9P[4], n=1) was observed in a total of 7 AGE patients aged between
14 - 29 months of age. These seven cases were distributed in Ahmadabad
(n=3), Surat (n=2), Pune (n=1), and Mumbai (n=1), and four of them with
severe disease outcomes were infected with HAdV-31 (Subgroup A), HAdV-69
(Subgroup D) and non typable penton strains.