mIBG Semiquantitative Scoring: Modified Curie Scoring Method
Curie scoring was performed from diagnostic and EOI mIBG scans as
previously described.12,13 SPECT was utilized only if
available and as needed for clarification of questionable sites of mIBG
uptake. An absolute score, calculated by summating the scores from the
ten individual anatomic sites, was determined. As in previous analyses,
relative score reductions were obtained by dividing the difference in
absolute score at EOI and diagnosis by the corresponding absolute score
at diagnosis.18 Curie scoring was performed by a
central scan review team, without knowledge of patient response or
outcome.