mIBG Semiquantitative Scoring: Modified Curie Scoring Method
Curie scoring was performed from diagnostic and EOI mIBG scans as previously described.12,13 SPECT was utilized only if available and as needed for clarification of questionable sites of mIBG uptake. An absolute score, calculated by summating the scores from the ten individual anatomic sites, was determined. As in previous analyses, relative score reductions were obtained by dividing the difference in absolute score at EOI and diagnosis by the corresponding absolute score at diagnosis.18 Curie scoring was performed by a central scan review team, without knowledge of patient response or outcome.